Regulatory T cells as immunotherapy.
Regulatory T cells as immunotherapy.
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DOI：
10.3389/fimmu.2014.00046
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发表时间：
2014
影响因子：
7.3
通讯作者：
D'Alessio FR
中科院分区：
文献类型：
--
作者：
Singer BD;King LS;D'Alessio FR
Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy. Conditions that require clinical tolerance to improve outcomes – autoimmune disease, solid organ transplantation, and hematopoietic stem cell transplantation – may benefit from Treg immunotherapy. Investigators have designed ex vivo strategies to isolate, preserve, expand, and infuse Tregs. Protocols to manipulate Treg populations in vivo have also been considered. Barriers to clinically feasible Treg immunotherapy include Treg stability, off-cell effects, and demonstration of cell preparation purity and potency. Clinical trials involving Treg adoptive transfer to treat graft versus host disease preliminarily demonstrated the safety and efficacy of Treg immunotherapy in humans. Future work will need to confirm the safety of Treg immunotherapy and establish the efficacy of specific Treg subsets for the treatment of immune-mediated disease.
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影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
影响因子：
8.8
作者：
Bloom, D. D.;Chang, Z.;Knechtle, S. J.
通讯作者：
Knechtle, S. J.
DOI：
10.1084/jem.20030152
发表时间：
2003-12-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen W;Jin W;Hardegen N;Lei KJ;Li L;Marinos N;McGrady G;Wahl SM
通讯作者：
Wahl SM
影响因子：
3.7
作者：
Brandt, Claudia;Liman, Peter;Baumgrass, Ria
通讯作者：
Baumgrass, Ria
影响因子：
5.4
作者：
BUSHELL, A;MORRIS, PJ;WOOD, KJ
通讯作者：
WOOD, KJ