Antioxidant properties of 3-hydroxycoumarin derivatives
Antioxidant properties of 3-hydroxycoumarin derivatives
复制标题
DOI：
10.1016/j.bmc.2004.07.066
复制
发表时间：
2004-11-01
影响因子：
3.5
通讯作者：
Cotelle, P
中科院分区：
文献类型：
--
作者：
Bailly, F;Maurin, C;Cotelle, P
3-芳基-2-羟基丙烯酸衍生物与三溴化硼反应，合成了一系列羟基3-羟基香豆素类化合物。评价了它们清除2，2-二苯基-1-苦基肼自由基、超氧阴离子自由基、羟基自由基和过氧亚硝酸根的能力，以及抑制铜诱导的人低密度脂蛋白过氧化的能力。这些物理化学结果表明，C-6和C-7位上的羟基化化合物是该系列化合物中活性最高的，其抗氧化能力可与槲皮素和维生素C相媲美。这些化合物清除自由基后形成邻苯二酮和对苯二酮衍生物，可作为新的先导化合物用于药理研究。(C)2004爱思唯尔有限公司。保留所有权利。
A series of hydroxylated 3-hydroxycoumarins was synthesised by the reaction of 3-aryl-2-hydroxypropenoic derivatives with boron tribromide. They were evaluated for their ability to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical, the superoxide anion radical, the hydroxyl radical and the peroxynitrite anion and to inhibit copper-induced human LDL peroxidation. The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C. These compounds form o- and p-quinonoid derivatives upon radical scavenging and may serve as new lead compounds for pharmacological investigations. (C) 2004 Elsevier Ltd. All rights reserved.