Transcriptional regulation of the transferrin receptor in differentiating HL-60 leukemic cells.
Transcriptional regulation of the transferrin receptor in differentiating HL-60 leukemic cells.
复制标题
转铁蛋白受体在分化 HL-60 白血病细胞中的转录调控。
DOI：
10.1016/s0006-291x(86)80594-0
复制
发表时间：
1986
影响因子：
3.1
通讯作者：
Sartorelli,AC
中科院分区：
文献类型：
--
作者：
Ho,PT;King,I;Sartorelli,AC
二甲亚砜诱导HL-60早幼粒细胞白血病细胞沿粒细胞途径分化。在暴露于诱导剂4小时后，转铁蛋白受体特异性mRNA显著降低。相对于未治疗的对照组，转录物水平在暴露于二甲亚砜的24小时内下降了5倍，并在整个6天的治疗期间保持低水平。受体转录本的减少先于表面受体的丧失，而表面受体的丧失又先于分化表型的表达。研究结果表明，转铁蛋白受体的分化相关调控可能发生在转录水平。
HL-60 promyelocytic leukemia cells were induced to differentiate along the granulocytic pathway by treatment with dimethylsulfoxide. A significant decrease in transferrin receptor specific mRNA was seen as early as 4 hr after exposure to inducer. Relative to untreated controls, transcript levels decreased 5-fold within 24 hr of exposure to dimethylsulfoxide and remained depressed throughout a 6-day treatment period. Reductions in receptor transcripts preceded the loss of surface receptor which in turn preceded the expression of the differentiated phenotype. The findings demonstrate that differentiation-associated regulation of the transferrin receptor can occur at the transcriptional level.