The study of ISO induced heart failure rat model
The study of ISO induced heart failure rat model
复制标题
DOI：
10.1016/j.yexmp.2009.10.011
复制
发表时间：
2010-04-01
影响因子：
3.6
通讯作者：
Li, Weimin
中科院分区：
文献类型：
--
作者：
Feng, Weiwei;Li, Weimin
目的：方法：雄性Wistar大鼠166只，随机分为4组，正常组（n = 10）、85/85 mg/kg组（n = 50）、85/340 mg/kg组（n = 50）和340/340 mg/kg组（n = 56）。通过连续2天皮下注射两次同源ISO诱导HF。计算各组动物在不同时间点的死亡率。分别于术后2、3、4周行超声心动图检查。我们定义了EF
Objective: To find a more excellent large-dose isoproterenol (ISO) induced heart failure (HF) rat model.Methods: 166 male Wistar rats were divided into four groups, normal group (n = 10), 85/85 mg/kg group (n = 50), 85/340 mg/kg group (n = 50) and 340/340 mg/kg group (n = 56). HF was induced by two subcutaneous injections of homologous ISO on 2 consecutive days. We calculated death rate of each ISO group on different time points. And all the survival ISO rats were examined by echocardiography separately on 2 weeks, 3 weeks and 4 weeks. We defined the EF