Synthesis of alkaloid 223A and a structural revision.
Synthesis of alkaloid 223A and a structural revision.
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生物碱223A的合成和结构修正。
DOI：
10.1021/ol025775m
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发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Kaneko,Tetsuo
中科院分区：
文献类型：
--
作者：
Toyooka,Naoki;Fukutome,Ayako;Nemoto,Hideo;Daly,JohnW;Spande,ThomasF;Garraffo,HMartin;Kaneko,Tetsuo
以原始的漆胺酯共轭加成反应为关键步骤，连续合成了生物碱223a。将天然223a的结构（A，绝对构型未知）修正为b，确定其相对立体结构为5R*、6R*、8R*、9S*。
Synthesis of alkaloid223Ahas been achieved by sequential use of our original conjugate addition reaction to enaminoesters as the key step. The proposed structure for natural223A(A, absolute configuration unknown) was revised toB, and the relative stereostructure was determined to be 5R*,6R*,8R*,9S* by the present synthesis.