In silico optimization for production of biomass and biofuel feedstocks from microalgae.
In silico optimization for production of biomass and biofuel feedstocks from microalgae.
复制标题
利用微藻生产生物质和生物燃料原料的计算机优化。
DOI：
10.1007/s10811-014-0342-2
复制
发表时间：
2015
影响因子：
3.3
通讯作者：
Kenny P
中科院分区：
文献类型：
--
作者：
Kenny P
优化富含N（例如蛋白质）或C（例如生物燃料）的生物质的生产率是使基于藻类的技术在商业上可行的关键。创造适当的条件来实现这一目标是一项挑战;操作排列是广泛的，而地理差异使利用自然光照的有效种植方法局限于本地。作为一种援助，以确定合适的操作信封，微藻生长的机械驯化模型是第一次使用虚拟系统在广泛的纬度范围内模拟生产。通过选择不同地理和季节光照分布的菌株特性、系统光学深度、营养供应和稀释制度来实现生产的优化。结果揭示了优化生物质与生物燃料生产的对比要求。在最大化面积和体积产量的同时节约资源，再加上反应器设计的流体动力学限制之间的权衡，导致最佳操作排列的可量化约束。模拟显示了如何选择具有高最大生长速率Um的菌株仍然是实现高生产率的主要因素。使用f/2生长培养基，将培养物稀释率设定为约25%的Um，为最佳生物量生产提供足够的营养。此外，对面积生产率和体积生产率之间的平衡的敏感性导致在约0.1 m处的明确定义的临界深度，在该临界深度处，使用低浓度f/4生长培养基结合约15%的Um稀释率，面积生物燃料生产达到峰值。这种分析及其发展将有助于开发一种决策支持工具，以实现更有效的种植方法。
Optimization of the production rate of biomass rich in N (e.g. for protein) or C (e.g. for biofuels) is key to making algae-based technology commercially viable. Creating the appropriate conditions to achieve this is a challenge; operational permutations are extensive, while geographical variations localise effective methods of cultivation when utilising natural illumination. As an aid to identifying suitable operational envelopes, a mechanistic acclimative model of microalgae growth is used for the first time to simulate production in virtual systems over a broad latitudinal range. Optimization of production is achieved through selection of strain characteristics, system optical depth, nutrient supply, and dilution regimes for different geographic and seasonal illumination profiles. Results reveal contrasting requirements for optimising biomass vs biofuels production. Trade-offs between maximising areal and volumetric production while conserving resources, plus hydrodynamic limits on reactor design, lead to quantifiable constraints for optimal operational permutations. Simulations show how selection of strains with a high maximum growth rate,Um, remains the prime factor enabling high productivity. Use of an f/2 growth medium with a culture dilution rate set at ~25 % ofUmdelivers sufficient nutrition for optimal biomass production. Further, sensitivity to the balance between areal and volumetric productivity leads to a well-defined critical depth at ~0.1 m at which areal biofuel production peaks with use of a low concentration f/4 growth medium combined with a dilution rate ~15 % ofUm. Such analyses, and developments thereof, will aid in developing a decision support tool to enable more productive methods of cultivation.