Autoradiographic localization of tritiated 7,12-dimethylbenz(a)-anthracene in mast cells of hairless mouse skin.
Autoradiographic localization of tritiated 7,12-dimethylbenz(a)-anthracene in mast cells of hairless mouse skin.
复制标题
无毛小鼠皮肤肥大细胞中氚化 7,12-二甲基苯(a)-蒽的放射自显影定位。
作者：
W. Tarnowski
将含有18µCi氚的7,12-二甲基苯(A)蒽单剂量200µg施用于雌性无毛小鼠皮肤。应用致癌物后每隔30分钟至72小时进行活检，并进行放射自显影。所有标本均有许多真皮肥大细胞标记，但不是全部。在表皮、毛囊和皮脂腺中也发现了这个标签，正如之前其他人所显示的那样。
A single 200-µg dose of tritiated 7,12-dimethylbenz(a)anthracene containing 18 µCi tritium was applied to the skin of female hairless mice. Biopsies were taken at intervals from 30 min to 72 hr after application of the carcinogen and processed for autoradiography. All specimens showed labeling of many, but not all, dermal mast cells. The label was also found in the epidermis, hair follicles, and sebaceous glands, as previously shown by others.