Signaling through the Primary Cilium.
Signaling through the Primary Cilium.
复制标题
DOI：
10.3389/fcell.2018.00008
复制
发表时间：
2018
影响因子：
5.5
通讯作者：
Hancock JT
中科院分区：
文献类型：
--
作者：
Wheway G;Nazlamova L;Hancock JT
自20世纪60年代以来，上皮细胞表面存在单一的、不运动的“初级”纤毛已经得到了很好的描述。然而，几十年来，这些细胞器被认为是退化的，没有剩余的功能，失去了运动性。直到2003年，人们才发现负责沿着初级纤毛运输的蛋白质是小鼠体内刺猬信号传导所必需的，初级纤毛在信号传导中的根本重要性才被认识到。十多年后，现在已经清楚的是，脊椎动物中绝大多数信号通路都是通过初级纤毛发挥作用的。这导致了“细胞的触角”一词被用来描述初级纤毛。初级纤毛在发育过程中特别重要，在胚胎形成和器官发生中起着重要作用，其中一系列遗传性发育障碍称为“纤毛病”，由编码纤毛蛋白的基因突变引起。这篇综述总结了我们目前对这些迷人的细胞器在广泛的信号通路中的作用的理解。
The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term “the cells's antenna” as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the “ciliopathies” resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.