Hypothesis: The role of reactive sulfur species in oxidative stress
Hypothesis: The role of reactive sulfur species in oxidative stress
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DOI：
10.1016/s0891-5849(01)00710-9
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发表时间：
2001-11-15
影响因子：
7.4
通讯作者：
Jacob, C
中科院分区：
文献类型：
--
作者：
Giles, GI;Tasker, KM;Jacob, C
氧化应激由促进氧化剂形成的氧化还原活性物质的代谢失衡引起。目前，这些物质被认为包括活性氧、活性氮和活性氮氧物质（分别为ROS、RNS和RNOS）。反应性物质起源于酶促合成、环境诱导或通过活性物质与其他内源性分子的进一步化学反应产生第二代反应性物质。这些第二代物种具有与亲本物种不同的活性谱，具有不同的氧化还原反应和生物靶点。我们现在提出，在氧化应激条件下，体内会形成另一组称为“反应性硫物质”（RSS）的氧化还原活性分子。RSS很可能包括二硫化物-S-氧化物、次磺酸和巯基自由基，并被预测为调节生物硫醇和二硫化物的氧化还原状态。(C)2001 Elsevier Science Inc.
Oxidative stress arises from an imbalance in the metabolism of redox-active species promoting the formation of oxidizing agents. At present, these species are thought to include reactive oxygen, reactive nitrogen, and reactive nitrogen oxygen species (ROS, RNS, and RNOS, respectively). Reactive species have their origin in enzymatic synthesis, environmental induction, or by the further chemical reaction of an active species with other endogenous molecules to generate a second-generation reactive species. These second-generation species possess a different spectrum of activity to the parent species, with different redox reactions and biological targets. We now propose that an additional group of redox active molecules termed " reactive sulfur species " (RSS) are formed in vivo under conditions of oxidative stress. RSS are likely to include disulfide-S-oxides, sulfenic acids, and thiyl radicals, and are predicted to modulate the redox status of biological thiols and disulfides. (C) 2001 Elsevier Science Inc.