The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics.
The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics.
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DOI：
10.3390/antiox6020033
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发表时间：
2017-05-17
期刊：
影响因子：
--
通讯作者：
Kashatus DF
中科院分区：
文献类型：
--
作者：
Nagdas S;Kashatus DF
线粒体是动态细胞器，可以根据各种细胞信号改变其组织。线粒体是许多生物过程的核心，例如细胞生物能量学和细胞凋亡，线粒体网络形态可以促进这些生理过程。一些部分由线粒体控制的生物过程在癌症中也通常会失调。此外，来自多种癌症的患者肿瘤样本表明，肿瘤中的线粒体动力学机制可能失调。在这篇综述中，我们将讨论常见突变的癌基因及其下游效应途径如何调节线粒体动力学机制以促进线粒体形态的变化，以及线粒体形态改变对致瘤性生长的生理后果。
Mitochondria are dynamic organelles that alter their organization in response to a variety of cellular cues. Mitochondria are central in many biologic processes, such as cellular bioenergetics and apoptosis, and mitochondrial network morphology can contribute to those physiologic processes. Some of the biologic processes that are in part governed by mitochondria are also commonly deregulated in cancers. Furthermore, patient tumor samples from a variety of cancers have revealed that mitochondrial dynamics machinery may be deregulated in tumors. In this review, we will discuss how commonly mutated oncogenes and their downstream effector pathways regulate the mitochondrial dynamics machinery to promote changes in mitochondrial morphology as well as the physiologic consequences of altered mitochondrial morphology for tumorigenic growth.