THE RECEPTOR TYROSINE KINASE P185(HER2) IS EXPRESSED ON A SUBSET OF B-LYMPHOID BLASTS FROM PATIENTS WITH ACUTE LYMPHOBLASTIC-LEUKEMIA AND CHRONIC MYELOGENOUS LEUKEMIA
THE RECEPTOR TYROSINE KINASE P185(HER2) IS EXPRESSED ON A SUBSET OF B-LYMPHOID BLASTS FROM PATIENTS WITH ACUTE LYMPHOBLASTIC-LEUKEMIA AND CHRONIC MYELOGENOUS LEUKEMIA
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DOI：
10.1182/blood.v86.5.1916.bloodjournal8651916
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发表时间：
1995-09-01
期刊：
影响因子：
20.3
通讯作者：
ULLRICH, A
中科院分区：
文献类型：
--
作者：
BUHRING, HJ;SURES, I;ULLRICH, A
I类受体酪氨酸激酶（RTK）HER 2是一种癌蛋白，经常参与上皮来源的肿瘤的发病机制。在此，我们报告了急性淋巴细胞白血病（ALL）、急性髓细胞白血病（AML）、慢性淋巴细胞白血病（CLL）、和慢性粒细胞白血病（CML）。然而，HER 2蛋白的细胞表面表达p185（HER 2）仅在B淋巴母细胞系的白血病细胞亚群上发现，在来自婴儿的15个样品中的2个、来自患有C-ALL的成人患者的19个样品中的9个（CD 19（+）CD 10（+））、而AML（0/30）、T-ALL（0/7）、CLL（0/5）（CD19（+）CD5（+））、p185（HER 2）在慢性期和加速期CML（0/ 5）及急变期伴髓系分化（0/14）中均为阳性。然而，来自4名处于B淋巴母细胞危象（CD 19（+）CD 10（+））的CML患者中的3名患者的细胞表达高水平的p185（HER 2），这也在CML衍生的B细胞系BV-173和Nalm-1的表面上发现。我们的研究表明，p185（HER 2）表达的恶性细胞的造血来源的第一次。这种致癌受体酪氨酸激酶在造血细胞类型中的异常表达可能是促成B淋巴母细胞白血病亚群发展的致癌事件。(C)1995年，美国血液学会。
The class I receptor tyrosine kinase (RTK) HER2 is an oncoprotein that is frequently involved in the pathogenesis of tumors of epithelial origin, Here we report mRNA expression in peripheral blood and bone marrow cells from healthy donors in hematopoietic cell lines acid leukemic blasts from patients with acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), chronic lymphoblastic leukemia (CLL), and chronic myeloid leukemia (CML). However, cell surface expression of HER2 protein (p185(HER2)) was found exclusively on a subset of leukemic cells of the B-lymphoblastic lineage, p185(HER2) expression was found on blasts in 2 of 15 samples from infants, 9 of 19 samples from adult patients with C-ALL (CD19(+)CD10(+)), and 1 of 2 samples from patients with pro-B ALL (CD19(+)CD10(-)), whereas none of the leukemic cells from patients with AML (0/30), T-ALL (0/7), CLL (0/5) (CD19(+)CD5(+)), or CML in chronic and accelerated phase (0/ 5) or in blast crisis with myeloid differentiation (0/14) were positive for p185(HER2). However, cells from 3 of 4 patients with CML in B-lymphoid blast crisis (CD19(+)CD10(+)) expressed high levels of p185(HER2), which was also found on the surface of the CML-derived B-cell lines BV-173 and Nalm-1. Our study shows p185(HER2) expression on malignant cells of hematopoietic origin for the first time. Aberrant expression of this oncogenic receptor tyrosine kinase in hematopoietic cell types may be an oncogenic event contributing to the development of a subset of B-lymphoblastic leukemias. (C) 1995 by The American Society of Hematology.