Annotating non-coding RNAs with Rfam.
Annotating non-coding RNAs with Rfam.
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DOI：
10.1002/0471250953.bi1205s9
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发表时间：
2005-04-01
影响因子：
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通讯作者：
Griffiths-Jones, Sam
中科院分区：
文献类型：
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作者：
Griffiths-Jones, Sam
非编码RNA(NcRNA)基因产生的是功能性的RNA产物，而不是翻译的蛋白质。这些基因的范围和重要性直到最近才显现出来，已知的ncRNAs参与了细胞内广泛的结构、调节和催化作用。与蛋白质编码基因一样，ncRNAs家族的多个序列比对告诉我们许多关于它们的结构和功能的信息，并使我们能够建立相关序列检测的统计模型。RFAM是一个ncRNAs家族数据库，由结构注释的多序列比对和协方差模型表示。
Non-coding RNA (ncRNA) genes produce a functional RNA product, rather than a translated protein. The range and importance of such genes is only recently apparent, with known ncRNAs participating in a wide range of structural, regulatory, and catalytic roles within the cell. Like protein-coding genes, multiple sequence alignments of families of ncRNAs tell us much about their structure and function, and enable the formulation of statistical models for the detection of related sequences. Rfam is a database of families of ncRNAs, represented by structure-annotated multiple sequence alignments and covariance models.