The clinical characteristics and outcomes of cases with pure ovarian clear cell, mixed type and high-grade serous adenocarcinoma
The clinical characteristics and outcomes of cases with pure ovarian clear cell, mixed type and high-grade serous adenocarcinoma
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DOI：
10.1007/s00404-015-3699-9
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发表时间：
2015-10-01
影响因子：
2.6
通讯作者：
Gumurdulu, Derya
中科院分区：
文献类型：
--
作者：
Gulec, Umran Kucukgoz;Paydas, Semra;Gumurdulu, Derya
本研究旨在比较单纯性卵巢透明细胞腺癌（OCCC）、混合型卵巢透明细胞腺癌（OCCC）和卵巢恶性肿瘤（OCCC）的临床特点和预后。方法回顾性分析32例单纯卵巢癌（OCCC）、10例卵巢恶性肿瘤（OCCC）的临床资料。1999年1月至2011年10月随访了23例MOC病例和28例HGSOC病例。比较三组患者的临床病理特征，包括组织病理学亚型、年龄、分期、是否存在腹水和/或腹膜癌转移、子宫内膜异位症和最佳细胞减灭术，以及生存率，单纯OCCC患者的年龄小于MOC和HGSOC患者（p = 0.004）。单纯OCCC的术前CA-125水平中位数低于MOC和HGSOC（p = 0.006）（分别为p = 0.001，p = < 0.001）。双侧和腹膜癌转移在HGSOC组中更常见（分别为p = 0.001，p < 0.001）。纯OCCC组中大多数病例（65%）为I期或II期疾病，但HGSOC组中大多数病例为晚期疾病（p < 0.001）。OCCC组中16例（16/55，29%）发生子宫内膜异位症.三组间的中位生存率无显著差异（p = 0.517），而疾病分期是影响生存的唯一重要因素（p = 0.002）。MOC的临床特征与HGSOC更相似。
This study aimed to compare the clinical characteristics and outcomes of the cases with pure ovarian clear cell adenocarcinoma (OCCC), mixed type (clear plus serous or clear plus endometrioid or serous plus clear plus endometrioid) ovarian adenocarcinoma (MOC) and high-grade serous ovarian adenocarcinoma (HGSOC).A retrospective comparison was conducted in 32 cases with pure OCCC, 23 cases with MOC and 28 cases with HGSOC followed between January 1999 and October 2011. Clinico-pathologic characteristics including histopathologic subtypes, age, stage, presence of ascites and/or peritoneal carcinomatosis, endometriosis and optimal cytoreduction, and also survival rates were compared in these three groups.The cases with pure OCCC were younger than the cases with MOC and HGSOC (p = 0.004). The median pre-operative CA-125 level was lower in the pure OCCC than in MOC and HGSOC (p = 0.006) (p = 0.001, p = < 0.001, respectively). Bilaterality and peritoneal carcinomatosis were more frequently seen in the HGSOC group (p = 0.001, p < 0.001, respectively). The majority of the cases (65 %) had stage I or II disease in the pure OCCC group, but most of the cases in the HGSOC group had advanced stage disease (p < 0.001). Endometriosis was found in 16 cases (16/55, 29 %) in the OCCC group. No significant difference was detected with regard to the median survival rate among three groups (p = 0.517), while the stage of disease was found to be the only important factor for survival (p = 0.002).Pure OCCC, MOC and HGSOC represent distinct clinical characteristics. Clinical characteristics of MOC are more similar to those of HGSOC.