A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence.
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence.
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DOI：
10.1093/nar/gks1039
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发表时间：
2013-01-07
影响因子：
14.9
通讯作者：
Mathee K
中科院分区：
文献类型：
--
作者：
Balasubramanian D;Schneper L;Kumari H;Mathee K
铜绿假单胞菌是一种代谢多样的细菌，存在于广泛的生物和非生物栖息地。它是一种主要的人类机会性病原体，引起许多急性和慢性感染。铜绿假单胞菌致病潜力的关键特征是产生无数毒力因子，形成生物膜和抗生素耐药性。这些性状的表达受到严格的调控，并对大部分未知的环境信号作出反应。本文综述了铜绿假单胞菌毒力基因调控的全球概况。除了控制从急性感染表型向慢性感染表型转变的关键调控途径外，已经确定了一些调节多种毒力机制的调控因子。尽管有混乱行为的倾向，但在铜绿假单胞菌毒力调控网络中没有很容易观察到混乱的基序。对调控级联的“鸟瞰图”为论坛提供了提出问题、制定假设和评估理论的机会，以阐明铜绿假单胞菌的发病机制。了解使铜绿假单胞菌成为成功病原体的机制对于帮助制定控制策略至关重要。
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing numerous acute and chronic infections. The critical traits contributing to the pathogenic potential of P. aeruginosa are the production of a myriad of virulence factors, formation of biofilms and antibiotic resistance. Expression of these traits is under stringent regulation, and it responds to largely unidentified environmental signals. This review is focused on providing a global picture of virulence gene regulation in P. aeruginosa. In addition to key regulatory pathways that control the transition from acute to chronic infection phenotypes, some regulators have been identified that modulate multiple virulence mechanisms. Despite of a propensity for chaotic behaviour, no chaotic motifs were readily observed in the P. aeruginosa virulence regulatory network. Having a ‘birds-eye’ view of the regulatory cascades provides the forum opportunities to pose questions, formulate hypotheses and evaluate theories in elucidating P. aeruginosa pathogenesis. Understanding the mechanisms involved in making P. aeruginosa a successful pathogen is essential in helping devise control strategies.
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