Rate of establishing the gut microbiota in infancy has consequences for future health.
Rate of establishing the gut microbiota in infancy has consequences for future health.
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DOI：
10.1080/19490976.2015.1078051
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发表时间：
2015
期刊：
影响因子：
12.2
通讯作者：
Holbrook JD
中科院分区：
文献类型：
--
作者：
Dogra S;Sakwinska O;Soh SE;Ngom-Bru C;Brück WM;Berger B;Brüssow H;Karnani N;Lee YS;Yap F;Chong YS;Godfrey KM;Holbrook JD
人类新生儿的肠道在出生后迅速定植，从早期的稀疏和高度不同的微生物群到更像成人和聚集的状态，在1到3年内。定植细菌物种的进程是非随机的。在生命的最初几个月里，在我们的肠道中普遍存在的物种通常会发生一些变化。尽管这些物种的顺序发展在不同的个体和地理位置上非常一致，但在发展速度上存在个体间的差异。我们的研究和其他研究表明，这一比率受到环境因素的影响，并影响我们未来的健康。在这篇文章中，我们回顾了我们最近对发育中的婴儿肠道微生物群编目的贡献以及其他重要的近期研究。我们提出了可检验的假设。
The gut of the human neonate is colonized rapidly after birth from an early sparse and highly distinct microbiota to a more adult-like and convergent state, within 1 to 3 years. The progression of colonizing bacterial species is non-random. During the first months of life several shifts commonly occur in the species prevalent in our guts. Although the sequential progression of these species is remarkably consistent across individuals and geographies, there is inter-individual variation in the rate of progression. Our study and others suggest that the rate is influenced by environmental factors, and influences our future health. In this article, we review our recent contribution to cataloging the developing infant gut microbiota alongside other important recent studies. We suggest testable hypotheses that arise from this synthesis.