Endocrine disrupting chemical exposure and maladaptive behavior during adolescence.
Endocrine disrupting chemical exposure and maladaptive behavior during adolescence.
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DOI：
10.1016/j.envres.2018.12.053
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发表时间：
2019-05
影响因子：
8.3
通讯作者：
J. Shoaff;A. Calafat;S. Schantz;S. Korrick
中科院分区：
文献类型：
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作者：
J. Shoaff;A. Calafat;S. Schantz;S. Korrick
研究表明，接触内分泌干扰化学物质（EDCs），包括邻苯二甲酸盐、酚类和对羟基苯甲酸酯可能会影响儿童的行为，但青春期的关系尚未得到评估。目的探讨青少年尿液中潜在EDCs（包括一些邻苯二甲酸盐和双酚A替代化学物质）的生物标志物浓度与行为之间的关系。方法研究对象来自新贝德福德队列（NBC），这是马萨诸塞州新贝德福德港超级基金站点附近居民的预期出生队列。我们测量了205名NBC青少年尿液中16种邻苯二甲酸酯代谢物或代谢物、8种酚类和4种对羟基苯甲酸酯的浓度，并用儿童行为评估系统第二版-教师评定量表（BASC-2）评估了所选EDCs与青少年行为之间的关系。值得注意的是，在我们评估的205个项目中，有多达32个缺少输入的结果信息。结果尿中11种抗雄激素邻苯二甲酸酯代谢物浓度总和的增加与适应不良行为（外化行为、行为症状指数和发育性社会障碍或DSD）的增加和适应技能的降低有关。例如，尿中抗雄激素邻苯二甲酸酯代谢物浓度增加一倍与外化行为风险增加有关（RR=1.04; 95% CI: 1.01-1.08）。虽然这种关联在男性中普遍更强，但性别差异在统计上并不显著。尿中酚类和对羟基苯甲酸酯的浓度与不良行为无关。结论：我们的研究结果支持青春期暴露于抗雄激素邻苯二甲酸盐的重要性，它可能与包括外化行为、DSD行为和适应技能下降在内的适应不良行为相关。
BackgroundStudies suggest that exposure to endocrine disrupting chemicals (EDCs), including phthalates, phenols, and parabens may influence childhood behavior, but the relationship during adolescence has not been assessed.ObjectiveWe investigated the association between urinary biomarker concentrations of potential EDCs, including some phthalate and bisphenol A replacement chemicals, and behavior in adolescents.MethodsParticipants were from the New Bedford Cohort (NBC), a prospective birth cohort of residents near the New Bedford Harbor Superfund site in Massachusetts. We measured urinary concentrations of 16 phthalate metabolites or replacements, 8 phenols, and 4 parabens in 205 NBC adolescents and estimated associations between select EDCs and adolescent behavior assessed with the Behavior Assessment System for Children, Second Edition -Teacher Rating Scale (BASC-2). Of note, up to 32 of the 205 in our assessment had missing outcome information imputed.ResultsIncreased urinary concentrations of the sum of 11 antiandrogenic phthalate metabolites were associated with an increase in maladaptive behaviors (Externalizing Behavior, Behavioral Symptoms Index, and Developmental Social Disorders or DSD), and a decrease in Adaptive Skills. For example, a doubling of urinary concentrations of antiandrogenic phthalate metabolites was associated with an increased risk of Externalizing Behavior (RR=1.04; 95% CI: 1.01–1.08). While associations were generally stronger in males, sex differences were not statistically significant. Urine concentrations of phenols and parabens were not associated with adverse behavior.ConclusionOur findings support the importance of exposure to antiandrogenic phthalates during adolescence as a potential correlate of maladaptive behaviors including Externalizing Behavior, DSD behaviors, and decrements in Adaptive Skills.