Gastric emptying: the validity of the paracetamol absorption test adjusted for individual pharmacokinetics
Gastric emptying: the validity of the paracetamol absorption test adjusted for individual pharmacokinetics
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DOI：
10.1046/j.1365-2982.2001.00249.x
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发表时间：
2001-06-01
影响因子：
3.5
通讯作者：
Husebye, E
中科院分区：
文献类型：
--
作者：
Medhus, AW;Lofthus, CM;Husebye, E
最近开发了一种用于胃排空的扑热息痛吸收试验的算法，可根据个体药代动力学进行调整。本研究的目的是验证该算法的使用。此外，该算法被用于阐明胃管是否干扰胃排空的速度。9名健康志愿者分别在两天内口服含扑热息痛的高热量液体餐。有一次，受试者用鼻胃管插管，并在进食45分钟后从胃中吸出食物。通过分析吸出液中的扑热息痛来确定吸出时胃中保留的膳食百分比，并与算法计算结果进行比较。在另一个检查日，同样的食物不经管吸而摄入。根据该算法计算的吸入时胃中保留的食物百分比中位数为47%（范围33-70%），根据吸入数据计算的百分比中位数为48%（范围23-61%）。各排空参数之间的相关性r=0.97 （P < 0.001）。当算法计算的样本数量减少时，胃排空参数的中位数相似，但范围有增大的趋势。胃管在进食后20 ~ 40 min有中度抑制胃排空（P < 0.05），但在进食至吸痰开始期间无抑制作用。本研究表明，新算法的对乙酰氨基酚吸收测试提供了有效的估计胃排空。
An algorithm for the paracetamol absorption test for gastric emptying, adjusting for individual pharmacokinetics, was recently developed. The aim of the present study was to validate the use of this algorithm. Furthermore, the algorithm was applied to elucidate whether a gastric tube interferes with the rate of gastric emptying. A caloric liquid meal with paracetamol was administered orally to nine healthy volunteers on two separate days. On one occasion, the subjects were intubated with a nasogastric tube and the meal was aspirated from the stomach 45 min after meal intake. The percentage of the meal retained in the stomach at the time of aspiration was determined by analyses of paracetamol in the aspirate and compared with calculations by the algorithm. On the other examination day, the same meal was ingested without tube and aspiration. The median percentage of the meal retained in the stomach at aspiration was 47% (range 33-70%) calculated by the algorithm and 48% (range 23-61%) based on the aspiration data. The correlation between the emptying parameters was r=0.97 (P < 0.001). The median of gastric emptying parameters was similar when the number of samples included in the calculation by the algorithm was reduced, but the range tended to increase. The gastric tube moderately inhibited gastric emptying during the period 20-40 min after meal intake (P < 0.05), but for the period from meal intake until start of aspiration, no inhibition was found. The present study demonstrates that the novel algorithm for the paracetamol absorption test provides valid estimates for gastric emptying.