[Mechanism of the radiation-protective effect of indralin].
[Mechanism of the radiation-protective effect of indralin].
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吲哚林的辐射防护作用机制[J].
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
N. N. Suvorov
中科院分区：
文献类型：
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作者：
M. V. Vasin;G. A. Chernov;L. V. Koroleva;T. S. L'vova;M. Abramov;V. V. Antipov;N. N. Suvorov
药理学试验表明，吲哚林的放射防护活性是通过与α-肾上腺素受体相互作用而发生的。 α-肾上腺素阻滞剂、氨嗪和茶碱可降低吲哚林的放射防护作用。照射过程中的常压高氧会降低 ED50 左右剂量的吲哚林的辐射防护作用。在对小鼠和大鼠的实验中表明，吲哚林会引起急性缺氧，耗氧量和产热能力下降30-46%，脾脏血流量降至对照水平的26.3%，直肠温度降低1.5-2摄氏度（小鼠）。 30分钟后，吲哚林提高了小鼠对缺氧的抵抗力，这被认为是由于缺氧细胞中生化适应过程的快速发展所致。
Pharmacological test demonstrated that radioprotective activity of indralin occurs by interaction with alpha-adrenoreceptor. Radioprotective effect of indralin decreased by alpha-adrenoblocker, aminazine and theophylline. Normobaric hyperoxia during irradiation reduced radioprotective effect of indralin in doses about ED50. In experiment with mice and rats it was shown that indralin induced acute hypoxia, impaired oxygen consumption and heat production by 30-46%, spleen bloodflow to 26.3% of control level, rectal temperature by 1.5-2 degrees C (mouse). After 30-min indralin raised resistance of mice to hypoxic hypoxia that is believed due to rapid development of biochemical adaptive process in hypoxic cells.