Odor-evoked responses in the olfactory center neurons in the terrestrial slug.
Odor-evoked responses in the olfactory center neurons in the terrestrial slug.
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DOI：
10.1002/neu.10295
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发表时间：
2004-02
期刊：
影响因子：
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通讯作者：
M. Murakami;Satoshi Watanabe;Tsuyoshi Inoue;Y. Kirino
中科院分区：
文献类型：
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作者：
M. Murakami;Satoshi Watanabe;Tsuyoshi Inoue;Y. Kirino
陆栖软体动物Limax的前脑(PC)是一个高度发达的二级嗅觉中枢，由两类不同的电生理神经元组成：非爆发型(NB)和爆发型(B)。到目前为止，NB神经元是两种细胞类型中数量更多的一种。它们接受来自初级嗅觉中枢触角神经节的传入纤维的直接突触输入，也接受来自B神经元的周期性抑制性突触后电位(IPSP)。用穿孔贴片记录方法检测了NB神经元的气味诱发活动。嗅觉刺激上触手可引起45%的NB神经元的抑制性反应，11%的NB神经元出现兴奋性反应。每个神经元对相同气味的反应都是可重复的，这表明NB神经元的活动可能编码了气味识别。对NB神经元周期平均膜电位的分析表明，IPSP之间的放电频率与平台期的膜电位之间存在相关性。此外，神经元的放电频率也受IPSP频率的影响。这些结果表明，存在两种不同的机制来调节NB神经元的活动。
The procerebrum (PC) of the terrestrial mollusk Limax is a highly developed second-order olfactory center consisting of two electrophysiologically distinct populations of neurons: nonbursting (NB) and bursting (B). NB neurons are by far the more numerous of the two cell types. They receive direct synaptic inputs from afferent fibers from the tentacle ganglion, the primary olfactory center, and also receive periodic inhibitory postsynaptic potentials (IPSPs) from B neurons. Odor-evoked activity in the NB neurons was examined using perforated patch recordings. Stimulation of the superior tentacle with odorants resulted in inhibitory responses in 45% of NB neurons, while 11% of NB neurons showed an excitatory response. The specific response was reproducible in each neuron to the same odorant, suggesting the possibility that activity of NB neurons may encode odor identity. Analysis of the cycle-averaged membrane potential of NB neurons revealed a correlation between the firing rate and the membrane potential at the plateau phase between IPSPs. Also, the firing rate of NB neurons was affected by the frequency of the IPSPs. These results indicate the existence of two distinct mechanisms for the regulation of NB neuron activity.