Effectiveness of Trivalent Influenza Vaccine among Children in Two Consecutive Seasons in a Community in Japan
Effectiveness of Trivalent Influenza Vaccine among Children in Two Consecutive Seasons in a Community in Japan
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DOI：
10.1620/tjem.232.97
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发表时间：
2014-02-01
影响因子：
2.2
通讯作者：
Saito, Reiko
中科院分区：
文献类型：
--
作者：
Suzuki, Tsubasa;Ono, Yasuhiko;Saito, Reiko
流感疫苗接种被认为是预防流感的最重要的医疗干预措施。自2011/12季节以来，日本儿童三价流感疫苗的剂量增加了近一倍。我们使用快速检测试剂盒估计了伊沙亚市1-11岁儿童的流感疫苗有效性，涉及28，884名儿童-年，连续两个流感季节（2011/12和2012/13）。根据接种记录，儿童被分为两组，接种疫苗和未接种疫苗，接种记录是从伊沙亚医学协会为该市所有儿科设施组织的流感登记项目中获得的。2011年和2012年，该市1-11岁儿童分别为14,562人和14,282人。在2011/12流感季，1-11岁儿童接种甲型和B型流感疫苗的总体有效性分别为23% [95%置信区间（CI）：14%-31%]和20% [95% CI：8%-31%]。在2012/13季节，甲型和B型流感疫苗的有效性分别为13%（95% CI：4%-20%）和9%（95% CI：4%-21%）。用快速诊断试剂盒评价疫苗效果。分层估计表明，在两个季节和两种病毒类型的幼儿中，疫苗的有效性是上级的。总之，在日本的一个社区，三价流感疫苗对1-11岁儿童在2011/12流感季感染甲型流感和B流感以及在2012/13流感季感染甲型流感具有显著的保护作用。
Influenza vaccination is considered the single most important medical intervention for the prevention of influenza. The dose of trivalent influenza vaccine in children was increased almost double since 2011/12 season in Japan. We estimated the influenza vaccine effectiveness for children 1-11 years of age using rapid test kits in Isahaya City, involving 28,884 children-years, over two consecutive influenza seasons (2011/12 and 2012/13). Children were divided into two groups, vaccinated and unvaccinated, according to their vaccination record, which was obtained from an influenza registration program organized by the Isahaya Medical Association for all pediatric facilities in the city. There were 14,562 and 14,282 children aged from 1-11 years in the city in 2011 and 2012 respectively. In the 2011/12 season, the overall vaccine effectiveness in children from 1-11 years of age, against influenza A and B were 23% [95% confidence interval (Cl): 14%-31%] and 20% [95% CI: 8%-31%], respectively. In the 2012/13 season, vaccine effectiveness against influenza A and B was 13% (95% Cl: 4%-20%) and 9% (95% Cl: 4%-21%), respectively. The vaccine effectiveness was estimated using the rapid diagnosis test kits. Age-stratified estimation showed that vaccine effectiveness was superior in younger children over both seasons and for both virus types. In conclusion, the trivalent influenza vaccine has a significant protective effect for children 1-11 years of age against influenza A and B infection in the 2011/12 season and against influenza A infection in the 2012/13 season in a community in Japan.