Longitudinal predictors of depressive symptoms among low income injection drug users
Longitudinal predictors of depressive symptoms among low income injection drug users
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DOI：
10.1080/09540120120063197
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发表时间：
2001-10-01
影响因子：
1.7
通讯作者：
Celentano, DD
中科院分区：
文献类型：
--
作者：
Knowlton, AR;Latkin, CA;Celentano, DD
在低收入注射吸毒者中评估了身体健康状况和药物使用的变化以及先前的社会支持对抑郁症状的影响。数据为基线（1994-1995年）入组的前参与者（n = 503），他们在一年随访时仍保持不变（79%），其中37%为HIV阳性，36%为女性。通过HIV症状、AIDS、CD 4计数和功能受限（IADL）来衡量身体健康。1年随访时，三分之一的患者抑郁症状评分较高（CES-D ≥ 16），与基线相比无统计学显著变化（38%）。在多元逻辑回归中，在控制了基线抑郁评分后，（OR = 6.11，p < 0.001）和药物使用（OR = 1.20，p = 0.192），基线功能受限（OR = 3.28，p < 0.001）和功能下降（OR = 3.60，p < 0.001）与随访时的抑郁症状呈正相关，而戒烟与随访时的抑郁症状呈负相关。基线时社会支持低（OR = 0.58，p < 0.10）对抑郁症状的预测作用不大。抑郁症状没有性别差异，对于HIT阳性的受访者，功能限制是抑郁症状的预测，但HIV疾病和药物使用不是。促进药物治疗和预防性医疗护理可能有助于减少这一人群的抑郁症。对于艾滋病毒阳性的吸毒者，在感染艾滋病之前接受药物治疗可能有助于减轻抑郁症状，对艾滋病毒服务的利用和医疗依从性可能产生影响，
Effects of changes in physical health status and drug use, and prior social support on depressive symptoms were assessed in low income injection drug users. Data are front participants (n = 503) enrolled at baseline (1994-1995) who remained at one-year follow-up (79%), of whom 37% were HIV-positive and 36% female. Physical health was measured by HIV symptoms, AIDS, CD4 count and functional limitation (IADLs). One-third scored high on depressive symptoms (CES-D greater than or equal to 16) at one-year follow-up, representing no statistically significant change from baseline (38%). In multiple logistic regression, after controlling for baseline depression scores (OR = 6.11, p < 0.001) and drug use (OR = 1.20, p = 0.192), baseline functional limitation (OR = 3.28, p < 0.001) and declining functioning (OR = 3.60, p < 0.001) were positively, and quitting drug use was negatively, associated with depressive symptoms at follow-up. Low social support at baseline (OR = 0.58, p < 0.10) was marginally predictive of depressive symptoms. Depressive symptoms did not differ by gender, For HIT positive respondents, functional limitation was predictive of depressive symptoms, but HIV illness and drug use were not. Facilitating drug treatment and preventive medical care may aid in reducing depression in this population. For HIV-positive drug users, drug treatment prior to AIDS may help reduce depressive symptoms, with potential implications for HIV service utilization and medical adherence,