Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections.
Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections.
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DOI：
10.3389/fimmu.2021.738955
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发表时间：
2021
影响因子：
7.3
通讯作者：
Pavot V
中科院分区：
文献类型：
--
作者：
Humphries DC;O'Connor RA;Larocque D;Chabaud-Riou M;Dhaliwal K;Pavot V
越来越多的证据表明，肺驻留记忆T和B细胞在防止呼吸道再感染中起着关键作用。凭借独特的转录和表型特征，常驻记忆淋巴细胞维持在静止状态，不断调查肺部的微生物入侵者。在用同源抗原再活化后，这些细胞提供快速效应子功能以增强免疫力和预防感染。旨在诱导它们形成的免疫策略，以及能够检测它们的新技术，有可能加速和改变疫苗的开发。尽管大多数数据来自小鼠的研究，本次审查将讨论最近的见解的产生，维护和表征的肺部常驻记忆淋巴细胞的背景下，呼吸道感染和疫苗接种使用最近的研究结果，从人类和非人类灵长类动物的研究。
There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent state, constantly surveying the lung for microbial intruders. Upon reactivation with cognate antigen, these cells provide rapid effector function to enhance immunity and prevent infection. Immunization strategies designed to induce their formation, alongside novel techniques enabling their detection, have the potential to accelerate and transform vaccine development. Despite most data originating from murine studies, this review will discuss recent insights into the generation, maintenance and characterisation of pulmonary resident memory lymphocytes in the context of respiratory infection and vaccination using recent findings from human and non-human primate studies.
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影响因子：
6.4
作者：
Gray JI;Westerhof LM;MacLeod MKL
通讯作者：
MacLeod MKL
影响因子：
120.7
作者：
Jackson, Lisa A.;Campbell, James D.;Bellamy, Abbie R.
通讯作者：
Bellamy, Abbie R.
影响因子：
15.9
作者：
Barker, Kimberly A.;Etesami, Neelou S.;Mizgerd, Joseph P.
通讯作者：
Mizgerd, Joseph P.
DOI：
10.1073/pnas.1611987113
发表时间：
2016-09-20
影响因子：
11.1
作者：
Foreman, Taylor W.;Mehra, Smriti;Kaushal, Deepak
通讯作者：
Kaushal, Deepak
影响因子：
82.9
作者：
Dijkman, Karin;Sombroek, Claudia C.;Verreck, Frank A. W.
通讯作者：
Verreck, Frank A. W.