Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism
Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism
复制标题
DOI：
10.1007/s10194-009-0136-0
复制
发表时间：
2009-10-01
影响因子：
7.4
通讯作者：
Pierelli, Francesco
中科院分区：
文献类型：
--
作者：
Di Lorenzo, Cherubino;Di Lorenzo, Giorgio;Pierelli, Francesco
药物过度使用性头痛（MOH）可以被认为是一种介于药物成瘾和慢性疼痛障碍之间的临床疾病。BDNF基因常见的196 G> A单核苷酸多态性（Val 66 Met）与行为障碍和药物滥用有关。为了确定MOH的恶化因素，而不是检测疾病发展的特定风险因素，我们研究了功能性BDNF多态性的存在是否可能决定90例MOH患者的临床差异，特别是每月药物消耗，这是疾病的标志。直接比较MOH患者G等位基因纯合子（G/G）和A等位基因携带者（非G/G），共观察到47种G/G基因型和60种非G/G基因型。非G/G患者的月用药数（Cohen’s d = 0.76）高于G/G患者。在多元回归分析中，Val 66 Met BDNF多态性是镇痛药物消耗量的重要独立预测因子（Beta = 0.33，Cohen's f（2）= 0.134）。这些结果表明，在MOH的临床特征中检测的BDNF多态性的影响，支持MOH是一种物质滥用障碍的想法。
Medication overuse headache (MOH) can be considered a clinical condition at the boundaries between drug addiction and chronic pain disorder. The common 196G > A single-nucleotide polymorphism of BDNF gene, resulting in a valine 66 to methionine (Val66Met), is related with behaviour disorders and substance abuse. With the aim of identifying a worsening factor in MOH, rather than the detection of a specific risk factor for the development of the disease, we investigated whether the presence of a functional BDNF polymorphism might determine clinical differences within a group of 90 MOH patients, particularly in monthly drug consumption, that is the hallmark of disease. Directly comparing MOH patients homozygous for G allele (G/G) with carriers of A allele (non-G/G), we have observed 47 G/G genotypes and 60 non-G/G genotypes. Non-G/G had a higher consumption of monthly drug number (Cohen's d = 0.76) than G/G patients. At multiple regression analysis, the Val66Met BDNF polymorphism emerged as a significant independent predictor of analgesic drug consumption (Beta = 0.33, Cohen's f (2) = 0.134). These findings showed an influence of examined BDNF polymorphism in the MOH clinical features, supporting the idea that MOH is a substance abuse disorder.