Long-Term Dynamics of Adaptation in Asexual Populations
Long-Term Dynamics of Adaptation in Asexual Populations
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DOI：
10.1126/science.1243357
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发表时间：
2013-12-13
期刊：
影响因子：
56.9
通讯作者：
Lenski, Richard E.
中科院分区：
文献类型：
--
作者：
Wiser, Michael J.;Ribeck, Noah;Lenski, Richard E.
近年来，在基因组工具日益强大的刺激下，进化的实验研究在数量上大大增加。然而，生物体的适应性仍然是解释这些实验的最终指标，在很长一段时间内，适应性的动态仍然知之甚少。在这里，我们研究健身轨迹12大肠杆菌种群在50,000代。平均适应性似乎无限制地增加，符合幂律。我们还推导出这种幂律关系理论上将克隆干扰和递减回报上位性的平均适应度随时间的变化的动态模型。
Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal fitness remains the ultimate metric for interpreting these experiments, and the dynamics of fitness remain poorly understood over long time scales. Here, we examine fitness trajectories for 12 Escherichia coli populations during 50,000 generations. Mean fitness appears to increase without bound, consistent with a power law. We also derive this power-law relation theoretically by incorporating clonal interference and diminishing-returns epistasis into a dynamical model of changes in mean fitness over time.