OPIOID AND NON-OPIOID MECHANISMS OF STRESS ANALGESIA
OPIOID AND NON-OPIOID MECHANISMS OF STRESS ANALGESIA
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DOI：
10.1126/science.7367889
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
LIEBESKIND, JC
中科院分区：
文献类型：
--
作者：
LEWIS, JW;CANNON, JT;LIEBESKIND, JC
大鼠不可避免的足底电击可产生深刻的镇痛作用，间歇给药30min可被纳洛酮或地塞米松所拮抗，而连续给药3min则无此作用。因此，仅根据其时间特性，足部电击应激似乎激活了阿片类或非阿片类镇痛机制。某些形式的应激可以作为内源性阿片类止痛系统的自然输入。
Inescapable foot shock in rats caused profound analgesia that was antagonized by naloxone or dexamethasone when shock was delivered intermittently for 30 minutes, but not when it was delivered continuously for 3 minutes. Thus, depending only on its temporal characteristics, foot-shock stress appears to activate opioid or nonopioid analgesia mechanisms. Certain forms of stress may act as natural inputs to an endogenous opiate analgesia system.