EXERCISE CAPACITY AND VENTILATORY, CIRCULATORY, AND SYMPTOM LIMITATION WITH CHRONIC AIR-FLOW LIMITATION
EXERCISE CAPACITY AND VENTILATORY, CIRCULATORY, AND SYMPTOM LIMITATION WITH CHRONIC AIR-FLOW LIMITATION
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DOI：
10.1164/ajrccm/146.4.935
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发表时间：
1992-10-01
期刊：
影响因子：
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通讯作者：
CAMPBELL, EJM
中科院分区：
文献类型：
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作者：
KILLIAN, KJ;LEBLANC, P;CAMPBELL, EJM
对97例慢性气流受限（CAL）患者（Fev 1为预测值的46.6 ± 14.23%）进行最大运动（自行车测力计）时的呼吸困难、腿部用力（博格0 ~ 10分）、通气量和心率（VE（max）/VE（cap）; HR（max）/HR（cap）表示为容量的百分比）测量，并与320例匹配的对照组进行比较。CAL患者的最大功率输出为86 +/- 39.5 W（预测值的60 +/- 23.2%）与140 +/- 37.5 W相比对照组（预测值的98 ± 14.5%）（p < 0.0001），VE（max）/VE（cep）分别为72 +/- 19.3%和53 +/- 18.6% HR（max）/HR（cap）分别为76 +/- 13.5%和82 +/- 13%（p < 0.001）。这些结果在预料之中。两组中呼吸困难的中位强度为6（重度至非常重度），腿部用力为7（非常重度），这些结果是非预期的。CAL患者的障碍是呼吸困难和外周肌肉努力相对于实际功率输出的增加。25例（26%）CAL受试者和69例（22%）对照受试者的呼吸困难评级超过腿部用力：42例（43%）CAL受试者和117例（36%）对照受试者的腿部用力评级超过呼吸困难; 30例（31%）CAL受试者和134例（42%）对照受试者的评级相等（NS）。VE（max）/VE（cap）和HR（max）/HR（cap）在受呼吸困难、腿部疲劳或两者组合限制的患者中无显著差异。所有值均表示为+/- SD。
Dyspnea, leg effort (Borg 0 to 10 scale), ventilation, and heart rate (VE(max) /VE(cap); HR(max)/HR(cap) expressed as a percentage of capacity) were measured at maximal exercise (cycle ergometer) in 97 patients with chronic airflow limitation (CAL) (Fev1 46.6 +/- 14.23% of predicted) and compared with 320 matched control subjects. Patients with CAL achieved a maximum power output of 86 +/- 39.5 W (60 +/- 23.2% of predicted) compared with 140 +/- 37.5 W (98 +/- 14.5% of predicted) in controls (p < 0.0001), VE(max)/VE(cep) was 72 +/- 19.3% compared with 53 +/- 18.6% (p < 0.0001), and HR(max)/HR(cap) was 76 +/- 13.5% compared with 82 +/- 13% (p < 0.001). These findings were expected. The median intensity of dyspnea was 6 (severe to very severe) and leg effort was 7 (very severe) in both groups, and these findings were unexpected. The patients with CAL were handicapped by an increase in both dyspnea and peripheral muscular effort relative to the actual power output. The rating of dyspnea exceeded leg effort in 25 (26%) of CAL versus 69 (22%) control subjects: the rating of leg effort exceeded dyspnea in 42 (43%) CAL and 117 (36%) control subjects; both were rated equally in 30 (31%) CAL and 134 (42%) control subjects, respectively (NS). VE(max)/VE(cap) and HR(max)/HR(cap) were not significantly different in those limited by dyspnea, leg fatigue, or a combination of both. All values are expressed +/- SD.