The effect of long-term low-dose lead exposure on thyroid function in adolescents
The effect of long-term low-dose lead exposure on thyroid function in adolescents
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DOI：
10.1016/j.envres.2005.10.002
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发表时间：
2006-05-01
影响因子：
8.3
通讯作者：
Ilhan, IE
中科院分区：
文献类型：
--
作者：
Dundar, B;Oktem, F;Ilhan, IE
本研究探讨长期从事汽车修理工作的低铅暴露男性青少年的血铅（Pb-B）水平及其对甲状腺功能的影响。Pb-B和ALAD指数（活化δ-氨基乙酰丙酸酯酶/非活化δ-氨基乙酰丙酸酯酶的对数）作为铅暴露的指标进行测量。甲状腺功能检查包括游离甲状腺素（FT 4）。对42名铅接触青少年和55名健康对照者进行了游离三碘甲状腺原氨酸（FT 3）和促甲状腺激素（TSH）测定及甲状腺超声检查。研究组的平均Pb-B水平和ALAD指数显著高于正常组。对照组（分别为7.3 ± 2.92 μ g/dl vs.2.08 ± 1.24 μ g/dl P < 0.001和0.44 ± 0.26 vs.0.29 ± 0.23，P < 0.05）。研究组的FT 4水平显著低于对照组（1.02 ± 0.18 mIU/mL和1.12 ± 0.14 mIU/mL，P < 0.05）。对照组中没有受试者的FT 4水平异常，但研究组中有11例受试者（26%）的FT 4水平低于正常范围。研究组与对照组间FT 3、TSH水平差异无统计学意义（P > 0.05）。甲状腺体积在实验组和对照组之间无显著性差异（P > 0.05）。相关分析显示，Pb-B与FT_4呈负相关（r =-0.20，P = 0.044）。本研究显示，长期低浓度铅暴露可导致青少年FT 4水平降低，即使在低Pb-B水平下，TSH和T3水平也无显著变化。(c)2005年爱思唯尔公司All rights reserved.
This study investigated blood lead (Pb-B) levels and Pb-B effects on thyroid functions in long-term low-level-lead-exposed male adolescents who work as auto repairers. Pb-B and ALAD index (logarithm of activated delta-aminolaevulinic acid dehydratase/nonactivated delta-aminolaevulinic acid dehydratase) were measured as indicators of exposure to lead. Thyroid function tests including free thyroxine (FT4). free triiodothyronine (FT3), and thyrotrophin (TSH) were conducted and thyroid ultrasounds were performed in 42 lead-exposed adolescents and 55 healthy control subjects. Mean Pb-B levels and ALAD index were found significantly higher in the study group than in the normal. control group (7.3 +/- 2.92 mu g/dl vs. 2.08 +/- 1.24 mu g/dl P < 0.001 and 0.44 +/- 0.26 vs. 0.29 +/- 0.23, P < 0.05, respectively). FT4 levels were found significantly lower in the study group (1.02 +/- 0.18 mI/mL and 1.12 +/- 0.14 mIU/mL, P < 0.05). No subject in the control group had an abnormal FT4 level, but FT4 levels were found under normal limits in 11 subjects (26%) in the study group. FT3 and TSH levels in the study and control groups did not differ (P > 0.05). Thyroid volumes in the study and control groups did not exhibit any significant differences (P > 0.05). Pb-B was found to be negatively correlated to FT4 levels (r = -0.20, P = 0.044). This study revealed that long-term low-level lead exposure may lead to reduced FT4 level without significant changes in TSH and T3 levels in adolescents even at low Pb-B levels. (c) 2005 Elsevier Inc. All rights reserved.