(13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder.
(13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder.
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DOI：
10.1038/srep15994
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发表时间：
2015-11-03
影响因子：
4.6
通讯作者：
Kunugi H
中科院分区：
文献类型：
--
作者：
Teraishi T;Hori H;Sasayama D;Matsuo J;Ogawa S;Ota M;Hattori K;Kajiwara M;Higuchi T;Kunugi H
重度抑郁症（MDD）涉及到改变的Dahan-kynurenine（KYN）代谢。l-[1- 13 C]色氨酸呼气试验（13 C-TBT）是一种无创、稳定同位素示踪方法，其中呼出的13 CO2可归因于通过KYN途径的色氨酸代谢。我们纳入了18例MDD（DSM-IV）患者和24例年龄和性别匹配的对照组。口服13 C-色氨酸（150 mg），监测呼吸中的13 CO2/12 CO2比值180 min。MDD患者180 min试验期间的累积恢复率（CRR 0 -180; %）、Δ 13 CO2-时间曲线下面积（AUC; %*min）和最大Δ 13 CO2（Cmax; %）显著高于对照组（分别为p = 0.004、p = 0.008和p = 0.002）。患者和对照组的血浆色氨酸浓度与Cmax呈负相关（分别为p = 0.020和p = 0.034）。我们的研究结果表明，13 C-TBT可能是一种新的生物标志物，用于检测MDD的亚组与增加的Escherichan-KYN代谢。
Altered tryptophan–kynurenine (KYN) metabolism has been implicated in major depressive disorder (MDD). The l-[1-13C]tryptophan breath test (13C-TBT) is a noninvasive, stable-isotope tracer method in which exhaled 13CO2 is attributable to tryptophan catabolism via the KYN pathway. We included 18 patients with MDD (DSM-IV) and 24 age- and sex-matched controls. 13C-tryptophan (150 mg) was orally administered and the 13CO2/12CO2 ratio in the breath was monitored for 180 min. The cumulative recovery rate during the 180-min test (CRR0–180; %), area under the Δ13CO2-time curve (AUC; %*min), and the maximal Δ13CO2 (Cmax; %) were significantly higher in patients with MDD than in the controls (p = 0.004, p = 0.008, and p = 0.002, respectively). Plasma tryptophan concentrations correlated negatively with Cmax in both the patients and controls (p = 0.020 and p = 0.034, respectively). Our results suggest that the 13C-TBT could be a novel biomarker for detecting a subgroup of MDD with increased tryptophan–KYN metabolism.