Gd-EOB-DTPA-enhanced MR imaging: Evaluation of hepatic enhancement effects in normal and cirrhotic livers
Gd-EOB-DTPA-enhanced MR imaging: Evaluation of hepatic enhancement effects in normal and cirrhotic livers
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DOI：
10.1016/j.ejrad.2011.01.020
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发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Sone, Teruki
中科院分区：
文献类型：
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作者：
Tamada, Tsutomu;Ito, Katsuyoshi;Sone, Teruki
目的：本研究的目的是探讨正常肝和肝硬化患者肝实质在Gd-EOB-DTPA增强MR成像（CE-MRI）上增强效果的差异。对58例Child-Pugh分级为A级30例，B级22例，C级6例的患者和41例正常肝脏进行Gd-EOB-DTPA增强扫描。造影剂注射前、动脉期（AP）25 s或改良扫描延迟、门脉期（PP）70 s、平衡期（EP）3 min、肝胆期（HP）3次（10、15、20 min）获取CE图像。结果：在正常肝脏和Child-Pugh A、B级患者中，肝实质的平均增强率随时间的延长而显著增加（P < 0.03-0.001），直至20 min HP。相反，Child-Pugh C级患者的平均RE在PP后未显示任何增加趋势。正常肝在EP和HP（10、15和20 min）时的平均RE值最高，Child-Pugh A、B、C级肝硬化次之（P < 0.02-0.001）。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The purpose of this study was to assess differences in enhancement effects of liver parenchyma between normal and cirrhotic livers on contrast-enhanced MR imaging (CE-MRI) obtained with Gd-EOB-DTPA.Methods: A total of 99 patients with cirrhotic liver (n = 58; Child-Pugh class A, n = 30; B, n = 22; C, n = 6) and normal liver (n = 41) underwent Gd-EOB-DTPA-enhanced MR imaging. CE images were obtained before contrast injection, in the arterial phase (AP) at 25 s or modified scan delay, in the portal phase (PP) at 70 s, in the equilibrium phase (EP) at 3 min, and in the hepatobiliary phase (HP) at 3 times (10, 15 and 20 min). Signal intensity of the liver in all phases was defined using region-of-interest measurements for relative enhancement (RE) calculation.Results: In normal-liver and Child-Pugh class A and B patients, mean RE of liver parenchyma increased significantly (P < 0.03-0.001) with time until 20-min HP. Conversely, mean RE for Child-Pugh class C patients did not show any increasing tendency after PP. Mean RE of liver parenchyma at EP and HP (10-, 15- and 20-min) was highest in normal liver, followed by Child-Pugh class A, B and C cirrhosis (P < 0.02-0.001).Conclusion: Hepatic parenchymal enhancement on CE-MR images obtained using Gd-EOB-DTPA is affected by the severity of cirrhosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.