Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.
Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.
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DOI：
10.4137/jcd.s11034
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hassan M
中科院分区：
文献类型：
--
作者：
El-Khattouti A;Selimovic D;Haikel Y;Hassan M
细胞凋亡和自噬都是高度保守的过程，除了它们在维持生物体和细胞内稳态中的作用之外，它们还作为肿瘤治疗的主要靶点。虽然它们在肿瘤治疗策略的调节中的重要作用已被广泛报道，但细胞凋亡和自噬的分子作用被癌症保护机制抵消。虽然细胞凋亡是一种涉及去除受损或不需要的细胞的严格调节的过程，但自噬是一种涉及溶酶体降解和蛋白质和细胞器再循环的细胞分解代谢途径，因此被认为是癌细胞响应代谢应激或化疗的重要存活/保护机制。尽管自噬和细胞死亡之间的关系非常复杂，并且尚未详细表征，但控制这种关系的分子机制被认为是开发肿瘤治疗策略的相关靶点。在这篇综述中，我们专注于细胞凋亡，自噬的分子机制，以及细胞凋亡和自噬之间的串扰，以提供深入了解的分子机制，可能是必不可少的细胞生存和死亡之间的平衡，以及它们的作用作为新的治疗方法的发展目标。
Both apoptosis and autophagy are highly conserved processes that besides their role in the maintenance of the organismal and cellular homeostasis serve as a main target of tumor therapeutics. Although their important roles in the modulation of tumor therapeutic strategies have been widely reported, the molecular actions of both apoptosis and autophagy are counteracted by cancer protective mechanisms. While apoptosis is a tightly regulated process that is implicated in the removal of damaged or unwanted cells, autophagy is a cellular catabolic pathway that is involved in lysosomal degradation and recycling of proteins and organelles, and thereby is considered an important survival/protective mechanism for cancer cells in response to metabolic stress or chemotherapy. Although the relationship between autophagy and cell death is very complicated and has not been characterized in detail, the molecular mechanisms that control this relationship are considered to be a relevant target for the development of a therapeutic strategy for tumor treatment. In this review, we focus on the molecular mechanisms of apoptosis, autophagy, and those of the crosstalk between apoptosis and autophagy in order to provide insight into the molecular mechanisms that may be essential for the balance between cell survival and death as well as their role as targets for the development of novel therapeutic approaches.