SYMBIOTIC MARINE-BACTERIA CHEMICALLY DEFEND CRUSTACEAN EMBRYOS FROM A PATHOGENIC FUNGUS
SYMBIOTIC MARINE-BACTERIA CHEMICALLY DEFEND CRUSTACEAN EMBRYOS FROM A PATHOGENIC FUNGUS
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DOI：
10.1126/science.2781297
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发表时间：
1989-10-06
期刊：
影响因子：
56.9
通讯作者：
FENICAL, W
中科院分区：
文献类型：
--
作者：
GILTURNES, MS;HAY, ME;FENICAL, W
虾Palaemon macrodactylus的胚胎对真菌Lagnidium callinectes的感染具有显著的抵抗力，Lagnidium callinectes是许多甲壳类动物的公认病原体。交替单胞菌属细菌菌株始终从胚胎表面分离，产生2，3-吲哚二酮（靛红），一种抑制致病真菌的化合物。如果暴露于真菌，无菌胚胎很快死亡，而用细菌重新接种或仅用2，3-吲哚二酮处理的类似胚胎则活得很好。细菌通过产生和释放抗真菌代谢物2，3-吲哚啉二酮来保护虾胚胎免受真菌感染。
Embryos of the shrimp Palaemon macrodactylus are remarkably resistant to infection by the fungus Lagnidium callinectes, a recognized pathogen of many crustaceans. An Alteromonas sp. bacterial strain consistently isolated from the surface of the embryos, produces 2,3-indolinedione (isatin), a compound that inhibits the pathogenic fungus. If exposed to the fungus, bacteria-free embryos quickly die, whereas similar embryos reinoculated with the bacteria or treated only with 2,3-indolinedione live well. The commensal Alteromonas sp. bacteria protect shrimp embryos from fungal infection by producing and liberating the antifungal metabolite 2,3-indolinedione.