Non-cancer thyroid diseases among children in the Kaluga and Bryansk regions of the Russian Federation exposed to radiation following the Chernobyl accident
Non-cancer thyroid diseases among children in the Kaluga and Bryansk regions of the Russian Federation exposed to radiation following the Chernobyl accident
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DOI：
10.1097/01.hp.0000142501.96410.ef
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发表时间：
2005-01-01
期刊：
影响因子：
2.2
通讯作者：
Shibata, Y
中科院分区：
文献类型：
--
作者：
Ivanov, VK;Chekin, SY;Shibata, Y
本文介绍了来自俄罗斯联邦卡卢加和布良斯克地区的人们在童年时期因切尔诺贝利事故而暴露于放射性碘的非癌症甲状腺疾病的辐射风险估计结果。这项工作是在Sasakawa纪念健康基金会和俄罗斯医学科学院医学放射研究中心进行的非癌症甲状腺疾病联合医学研究项目下进行的。受试者为2，457人，他们从1997年到1999年底进行了健康检查，在1986年5月至6月期间获得了甲状腺放射性测量数据，并且在暴露时年龄为10岁或更小。根据受试者甲状腺和肝脏附近的暴露剂量率测量值，估算了结合I-131的甲状腺吸收剂量。使用了一个房室模型来解释人和奶牛中I-131的代谢。估计剂量范围为0 ~ 6戈伊，其分布近似为对数正态分布，平均值为0.132戈伊，标准差为0.45戈伊。男性弥漫性甲状腺肿的患病率显示出显著的剂量反应（p = 0.03），在1戈伊剂量下估计比值比为1.36。
This paper presents results of estimated radiation risks of non-cancer thyroid diseases in the people from Kaluga and Bryansk regions of the Russian Federation exposed in their childhood to radioiodine as a result of the Chernobyl accident. This work was carried out under the Joint Medical Research Project on non-cancer thyroid diseases conducted by Sasakawa Memorial Health Foundation and the Medical Radiological Research Center of the Russian Academy of Medical Sciences. The subjects were 2,457 people who underwent health examinations from 1997 to the end of 1999 who had individual radiometric thyroid data obtained between May and June 1986 and were aged 10 y or less at the time of exposure. The thyroid absorbed doses from incorporated I-131 were estimated on the basis of measurements of exposure dose rate in the vicinity of the subject's thyroid and liver. A compartment model accounting for I-131 metabolism in humans and cows was used. The estimated dose varied from 0 to 6 Gy, and its distribution was approximately lognormal with a mean of 0.132 Gy and standard deviation of 0.45 Gy. The prevalence of diffuse goiter in males showed a significant dose-response (p = 0.03) with an estimated odds ratio 1.36 at 1 Gy.