Cascade Reaction between Methyl 3-Dehydroshikimate, Arylamines, and 2-Chloroalkyl Esters under Microwave Conditions: A Practical and Biomass-Based Synthesis of N-Aryl-1,4-benzoxazin-3-ones
Cascade Reaction between Methyl 3-Dehydroshikimate, Arylamines, and 2-Chloroalkyl Esters under Microwave Conditions: A Practical and Biomass-Based Synthesis of N-Aryl-1,4-benzoxazin-3-ones
复制标题
DOI：
10.1055/s-0033-1338606
复制
发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Ensheng Zhang;Xu Tianlong;Wei Wen;Huang Tongkun;Mu Yuan;Weizhen Zeng;Yong Zou
中科院分区：
文献类型：
--
作者：
Ensheng Zhang;Xu Tianlong;Wei Wen;Huang Tongkun;Mu Yuan;Weizhen Zeng;Yong Zou
摘要以3-脱氢莽草酸甲酯（3-MHDS）为原料，通过脂肪族到芳香族的转化以及C-O和C-N的形成反应，合成了N-芳基-1，4-苯并恶嗪-3-酮化合物。在微波条件下，采用一锅法连续高效合成了N-芳基-1，4-苯并恶嗪-3-酮。
Abstract A biomass-based, metal- and ligand-free assembly of N-aryl-1,4-benzoxazin-3-ones from methyl 3-dehydroshikimate (3-MHDS), involving aliphatic to aromatic transformation followed by C–O and C–N forming reactions, is presented. A variety of N-aryl-1,4-benzoxazin-3-ones were efficiently synthesized in a one-pot consecutive manner under microwave conditions.