A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
A report of cytokine polymorphisms and COPD risk in Xuan Wei, China
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DOI：
10.1016/j.ijheh.2007.05.002
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发表时间：
2008-07-01
影响因子：
6
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Shen, Min;Vermeulen, Roel;Lan, Qing
室内空气污染已被证明是慢性阻塞性肺疾病（COPD）的重要危险因素，而炎症是COPD发展和进展的核心。一些细胞因子基因的单核苷酸多态性（SNP）已被报道与COPD相关。我们在一项对高暴露于室内煤烟排放的人群进行的病例对照研究中，研究了10个细胞因子基因中的18个SNP与COPD风险之间的关联。该研究包括53例COPD病例和122例健康社区对照。CSF 2 117 Ile等位基因携带者患COPD的风险是野生型（Thr/Thr）携带者的2.4倍（OR：2.44; 95% CI：1.10-5.41），IL 8 -351的AA基因型与COPD风险增加相关（OR：2.71; 95% CI：1.04-7.04）。当检查CSF 2 117 Ile和IL 8 - 351 A的联合作用时，在两种基因中携带至少一种变体的个体患COPD的风险增加5倍（OR：5.14，95%CI：1.32-29.86）。这项研究表明，CSF 2和IL 8的多态性可能在COPD的发病机制中发挥作用，至少在高暴露人群中。然而，鉴于我们的样本量相对较小，这项研究应该在其他大量暴露于室内空气污染物（如多环芳烃（PAH）和颗粒物）的人群中重复。(C)2007年，Elsevier GmbH。All rights reserved.
Indoor air pollution has been documented as an important risk factor for chronic obstructive pulmonary disease (COPD), and inflammation is central to the development and progression of COPD. Single nucleotide polymorphisms (SNP) in some cytokine genes have been reported to be associated with COPD. We examined the association between 18 SNPs in 10 cytokine genes and COPD risk in a case-control study conducted in a population with high exposure to indoor smoky coal emissions. The study included 53 COPD cases and 122 healthy community controls. Carriers of the CSF2 117Ile allele had a 2.4-fold higher risk of COPD than the wild type (Thr/Thr) carriers (OR: 2.44; 95% CI: 1.10-5.41), and the AA genotype at IL8-351 was associated with an increased risk of COPD (OR: 2.71; 95% CI: 1.04-7.04). When the combined effects of CSF2 117Ile and IL8-351A were examined, individuals carrying at least one variant in both genes had a five-fold increased risk of COPD (OR: 5.14, 95% CI: 1.32-29.86). This study suggests that polymorphisms in both CSF2 and IL8 may play a role in the pathogenesis of COPD, at least in highly exposed populations. However, in view of our relatively small sample size, this study should be replicated in other populations with substantial exposure to indoor air pollutants such as polycyclic aromatic hydrocarbons (PAH) and particulate matter. (C) 2007 Elsevier GmbH. All rights reserved.