Electrochemical biosensors: Towards point-of-care cancer diagnostics
Electrochemical biosensors: Towards point-of-care cancer diagnostics
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DOI：
10.1016/j.bios.2005.10.027
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发表时间：
2006-04-15
影响因子：
12.6
通讯作者：
Wang, J
中科院分区：
文献类型：
--
作者：
Wang, J
大规模的床旁诊断系统为在疾病的可治愈阶段早期检测癌症带来了巨大的希望。本文综述了电化学生物传感器用于下一代癌症诊断的前景和挑战。电化学生物传感器在向即时诊断设备的转变中发挥了重要作用。这样的电气设备对于以快速、简单和低成本的方式与紧凑（手持式）分析仪连接地传递诊断信息是非常有用的。现代电化学生物亲和传感器，如DNA或免疫传感器，提供了早期癌症检测所必需的显着灵敏度。电化学装置与纳米级材料的耦合提供了一种独特的多路复用能力，用于同时测量多种癌症标志物。电化学装置的吸引人的特性对于提高癌症诊断和治疗监测的效率非常有希望。随着进一步的发展和资源，这种便携式设备有望加快癌症的诊断，使分析结果在几分钟内在病人床边或医生办公室。(c)2005 Elsevier B.V.保留所有权利。
Wide-scale point-of-care diagnostic systems hold great promise for early detection of cancer at a curable stage of the disease. This review discusses the prospects and challenges of electrochemical biosensors for next-generation cancer diagnostics. Electrochemical biosensors have played an important significant role in the transition towards point-of-care diagnostic devices. Such electrical devices are extremely useful for delivering the diagnostic information in a fast, simple, and low cost fashion in connection to compact (hand-held) analyzers. Modem electrochemical bioaffinity sensors, such as DNA- or immunosensors, offer remarkable sensitivity essential for early cancer detection. The coupling of electrochemical devices with nanoscale materials offers a unique multiplexing capability for simultaneous measurements of multiple cancer markers. The attractive properties of electrochemical devices are extremely promising for improving the efficiency of cancer diagnostics and therapy monitoring. With further development and resources, such portable devices are expected to speed up the diagnosis of cancer, making analytical results available at patient bedside or physician office within few minutes. (c) 2005 Elsevier B.V. All rights reserved.