New insights into the mechanism for chromosome alignment in metaphase.
New insights into the mechanism for chromosome alignment in metaphase.
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DOI：
10.1016/b978-0-12-407697-6.00006-4
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发表时间：
2013
影响因子：
--
通讯作者：
Mao, Yinghui
中科院分区：
文献类型：
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作者：
Guo, Yige;Kim, Christine;Mao, Yinghui
在有丝分裂过程中，复制的姐妹染色单体在分裂纺锤体的中期板上正确排列，然后分离成两个子细胞。这需要一个复杂的过程来确保染色体和纺锤体微管之间的正确相互作用。着丝粒，即在每个染色体上的着丝粒区域组装的蛋白质复合物，作为微管附着位点并在有丝分裂中为染色体运动提供动力。许多蛋白质/蛋白质复合物已被牵连在着丝粒和动态微管之间的连接。近年来的研究进一步加深了我们对着丝粒与微管正末端之间的界面在促进和维持其稳定附着中的性质的理解。这些努力已经证明了这一过程的重要性，以确保准确的染色体分离，这对于理解和控制人类遗传疾病和癌症进展中的异常染色体分离（非整倍性）具有重要意义的问题。
During mitosis, duplicated sister chromatids are properly aligned at the metaphase plate of the mitotic spindle before being segregated into two daughter cells. This requires a complex process to ensure proper interactions between chromosomes and spindle microtubules. The kinetochore, the proteinaceous complex assembled at the centromere region on each chromosome, serves as the microtubule attachment site and powers chromosome movement in mitosis. Numerous proteins/protein complexes have been implicated in the connection between kinetochores and dynamic microtubules. Recent studies have advanced our understanding on the nature of the interface between kinetochores and microtubule plus ends in promoting and maintaining their stable attachment. These efforts have demonstrated the importance of this process to ensure accurate chromosome segregation, an issue which has great significance for understanding and controlling abnormal chromosome segregation (aneuploidy) in human genetic diseases and in cancer progression.