Obesity, weight gain, and ovarian cancer
Obesity, weight gain, and ovarian cancer
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DOI：
10.1016/s0029-7844(02)02053-7
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发表时间：
2002-08-01
影响因子：
7.2
通讯作者：
Hankinson, SE
中科院分区：
文献类型：
--
作者：
Fairfield, KM;Willett, WC;Hankinson, SE
目的：研究脂肪组织如何改变内源性激素水平，并可能影响卵巢组织水平的事件。方法：我们评估了目前的体重，18岁时的体重，成人体重变化与卵巢癌风险之间的关系，109,445名护士健康研究参与者。1976年至1996年，妇女在两年一次的邮寄问卷中报告卵巢癌危险因素和新的卵巢癌诊断。1976年对身高和体重进行了调查，目前的体重每两年更新一次，18岁时的体重于1980年确定。在20年的随访和1，703，474人年的随访中，402例上皮性卵巢癌被证实。我们使用混合logistic回归来控制年龄、口服避孕药使用、吸烟史、产次、初潮年龄和输卵管结扎。BMI ≥ 30 kg/m2的女性与BMI <21 kg/m2的女性的多变量相对危险度为1.05（95%可信区间0.73，1.51）。对于18岁时的BNH，总体上与卵巢癌风险无关，但18岁时BMI ≥ 25 kg/m2与BMI <20 kg/m2相比，绝经前卵巢癌风险增加2倍（相对风险2.05，950，16置信区间1.07，3.93，趋势P = 0.01）。成人体重增加与卵巢癌风险无关。结论：我们没有发现近期BNH或成人体重变化与卵巢癌风险相关的证据。青年期较高的BNH与绝经前卵巢癌的风险增加有关。如果得到证实，这些发现表明避免青少年肥胖的另一个原因。(C)2002年由美国妇产科医师学会。
OBJECTIVE: To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level.METHODS: We assessed current weight, weight at age 18, and adult weight change in relation to ovarian cancer risk among 109,445 participants in the Nurses' Health Study. Women reported ovarian cancer risk factors and new ovarian cancer diagnoses in biennial mailed questionnaires from 1976 to 1996. Height and weight were queried in 1976, current weight was updated biennially, and weight at age 18 was ascertained in 1980. During 20 years of follow-up and 1,703,474 person-years, 402 cases of epithelial ovarian cancer were confirmed, We used pooled logistic regression to control for age, oral contraceptive use, smoking history, parity, age at menarche, and tubal ligation.RESULTS: We found no evidence of an association between recent body mass index (BMI, kg/m(2)) and ovarian cancer risk. The multivariable relative risk for women with BMI of 30 kg/m(2) or higher versus BMI less than 21 kg/m(2) was 1.05 (95% confidence interval 0.73,1.51). For BNH at age 18, there was no association with ovarian cancer risk overall, but a two-fold increase in premenopausal ovarian cancer risk associated with having a BMI at age 18 of 25 kg/m(2) or higher versus BMI less than 20 kg/m(2) (relative risk 2.05, 950,16 confidence interval 1.07, 3.93, P for trend = .01). Adult weight gain was not associated with ovarian cancer risk.CONCLUSION: We found no evidence of an association between recent BNH or adult weight change and ovarian cancer risk. Higher BNH in young adulthood was associated with an increased risk of premenopausal ovarian cancer. If confirmed, these findings suggest an additional reason for avoiding adolescent obesity. (C) 2002 by The American College of Obstetricians and Gynecologists.