Manganese-Doped Carbon Dots with Redshifted Orange Emission for Enhanced Fluorescence and Magnetic Resonance Imaging
Manganese-Doped Carbon Dots with Redshifted Orange Emission for Enhanced Fluorescence and Magnetic Resonance Imaging
复制标题
具有红移橙色发射的锰掺杂碳点，用于增强荧光和磁共振成像。
DOI：
10.1021/acsabm.0c01597
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发表时间：
2021-02-04
影响因子：
4.7
通讯作者：
Zeng, Leyong
中科院分区：
文献类型：
--
作者：
Sun, Sijia;Zhao, Lining;Zeng, Leyong
金属掺杂碳点（CDs）在荧光和磁共振（MR）成像中具有良好的应用前景，但开发具有长波发射和增强MR性能的掺杂锰碳点（Mn-CDs）是一个挑战。本文采用一步溶剂热法合成了具有红移橙色发射和增强纵向弛豫的Mn-CDs，用于荧光和MR成像。结果表明：制备的Mn-CDs具有均匀的粒径分布，平均粒径为5 nm；此外，Mn-CDs具有比无mn CDs更强的荧光性能，同时，由于n掺杂的增加，发射波长可以从542 nm（绿色发射）红移到578 nm（橙色发射）。由于Mn2+的运动限制，Mn-CDs表现出较高的t1加权MR成像性能，其纵向弛豫率为12.69 mM-1·s-1。体内实验证明其具有良好的荧光和磁共振成像性能，安全可靠。因此，所制备的具有橙色发射的Mn-CDs可以作为荧光和磁共振成像的双峰纳米探针。
Metal-doped carbon dots (CDs) exhibited promising application in fluorescence and magnetic resonance (MR) imaging, but developing manganese-doped CDs (Mn-CDs) with long wavelength emission and enhanced MR performance is a challenge. Herein, using a one-step solvothermal method, Mn-CDs with redshifted orange emission and enhanced longitudinal relaxation were synthesized for fluorescence and MR imaging. The results indicated that the prepared Mn-CDs had a uniform size distribution, and the average size was 5 nm. Moreover, Mn-CDs possessed a stronger fluorescence performance than Mn-free CDs, and simultaneously, the emission wavelength can redshift from 542 nm (green emission) to 578 nm (orange emission), owing to the increasing N-doping. Because of the movement limit of Mn2+, Mn-CDs exhibited high T1-weighted MR imaging performance with a longitudinal relaxation rate of 12.69 mM-1·s-1. The in vivo experiments demonstrated their excellent fluorescence and MR imaging with safety and reliability. Therefore, the prepared Mn-CDs with orange emission can be an excellent candidate as a dual-modal nanoprobe for fluorescence and MR imaging.