Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence
Volumetric differences in the anterior cingulate cortex prospectively predict alcohol-related problems in adolescence
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DOI：
10.1007/s00213-014-3483-8
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发表时间：
2014-04-01
影响因子：
3.4
通讯作者：
Lubman, Dan I.
中科院分区：
文献类型：
--
作者：
Cheetham, Ali;Allen, Nicholas B.;Lubman, Dan I.
大脑结构和功能的个体差异被认为存在于酒精滥用发作之前。横断面研究表明，情感过程的大脑区域异常，可能形成一个途径，以出现后来的酒精滥用和依赖的弱势个体。然而，没有前瞻性的研究已经检查这些异常是否预测以后的问题与alcohol.This研究的目的是检查是否在影响和脑容量的个体差异前瞻性预测酒精相关的问题，在adolescence.Adolescent饮酒者（n = 98）被招募从一个正在进行的前瞻性，纵向研究青少年的情绪发展。在12岁时，参与者接受了结构磁共振成像，以获得杏仁核，海马，眶额皮质和前扣带皮质（ACC）的体积数据，并完成了情感气质的自我报告测量。在16岁时，参与者完成了一份测量酒精使用情况的问卷，其中39%的人报告在过去一年中有酒精相关的问题。酒精相关的问题与较高水平的气质负affectivities，然而，这些都不相关的前扣带volumes.These研究结果表明，个体差异的结构形态的前扣带，一个区域牵连的情感过程，自我控制，和药物成瘾，预测以后酒精相关的问题。尽管在控制了其他物质使用和精神病理学后，这一发现仍然很重要，但未来的研究需要测试其对酒精使用障碍的特异性。
Individual differences in brain structure and function are suggested to exist prior to the onset of alcohol abuse. Cross-sectional studies have demonstrated abnormalities in brain regions underlying affective processes that may form a pathway to the emergence of later alcohol abuse and dependence in vulnerable individuals. However, no prospective studies have examined whether these abnormalities predict later problems with alcohol.This study aims to examine whether individual differences in affect and brain volume prospectively predict alcohol-related problems in adolescence.Adolescent drinkers (n = 98) were recruited from an ongoing prospective, longitudinal study examining adolescent emotional development. At age 12, participants underwent structural magnetic resonance imaging to obtain volumetric data on the amygdala, hippocampus, orbitofrontal cortex, and anterior cingulate cortex (ACC), and completed a self-report measure of affective temperament. At age 16, participants completed a questionnaire measuring alcohol use, with 39 % reporting alcohol-related problems in the past year.Pre-existing differences in the left ACC predicted problem drinking. Alcohol-related problems were associated with higher levels of temperamental negative affectivity; however, these were not correlated with anterior cingulate volumes.These findings indicate that individual differences in the structural morphology of the anterior cingulate, a region implicated in affective processes, self-control, and drug addiction, predict later alcohol-related problems. Although this finding remained significant after controlling for other substance use and psychopathology, future research is required to test its specificity for alcohol use disorders.