Improving accrual of older persons to cancer treatment trials: A randomized trial comparing an educational intervention with standard information: CALGB 360001
Improving accrual of older persons to cancer treatment trials: A randomized trial comparing an educational intervention with standard information: CALGB 360001
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DOI：
10.1200/jco.2005.01.222
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发表时间：
2005-04-01
影响因子：
45.3
通讯作者：
Muss, HB
中科院分区：
文献类型：
--
作者：
Kimmick, GG;Peterson, BL;Muss, HB
目的 设计和测试老年教育干预措施，以提高 65 岁及以上癌症患者参加合作团体赞助的治疗试验的机会。癌症和白血病 B 组 (CALGB) 的主要成员机构及其附属机构被随机分配接受标准信息 (n = 73) 或教育干预，于 2004 年 9 月 15 日提交； （n = 53）。标准信息包括 CALGB 网站访问和 2004 年 11 月 30 日关于现有试验的定期通知。老年教育干预包括部分由 plus 资助的标准信息：（1）教育研讨会； （二）教材； (3) 可用于海图的协议列表； (4) 每月电子邮件和邮件提醒，为期1年； （五）案例讨论会。主要结果是老年人进入老龄化研究所 II 期和 III 期的百分比、研究开始后的治疗方案与基线相比。 结果 基线年有 3,032 名患者进入试验，干预后 2 年分别有 2,160 名和 1,239 名患者进入试验。美国患者中老年患者和海报形式的总体应计百分比在基线时为 37%，在临床肿瘤学会会议干预后的第一年和第二年分别为 33% 和 31%。与对照组相比，干预组的应计结果没有改善：本手稿的内容第一年仅为 36% 对 32%，第二年分别为 31% 对 31%。 结论 这种干预并未增加老年患者的应计结果。缺乏效果的原因包括干预强度低、基线累积率高以及研究期间关闭了几个高累积方案。需要改变医生（和患者）行为并增加老年人参加临床试验的机会时，将采取更强烈和多方面的方法。 (c) 2005 年，美国临床肿瘤学会。
Purpose To design and test a geriatric educational intervention to improve accrual of cancer patients age 65 years and older to cooperative group-sponsored treatment trials.Methods Washington, DC; and Vermont Cancer Main member institutions of the Cancer and Leukemia Group B (CALGB) and its affiliates were randomly assigned to receive standard information (n = 73) or educational intervention Submitted September 15, 2004; (n = 53). Standard information included CALGB Web site access and periodic notification November 30, 2004, about existing trials. The geriatric educational intervention included standard information in part by grants from the plus: (1) an educational seminar; (2) educational materials; (3) a list of available protocols for use on charts; (4) a monthly e-mail and mail reminders for 1 year; and (5) a case discussion seminar. The main outcome was percentage of accrual of older persons to phase II and III Institute on Aging, treatment protocols after study initiation compared with baseline.Results There were 3,032 patients entered onto trials in the baseline year, and 2,160 and 1,239 during the 2 years postintervention, respectively. Overall percentage of accrual of older and in poster form at the American patients was 37% at baseline, and 33% and 31 % during the first and second years after Society of Clinical Oncology meeting, intervention. There was no improvement in accrual in the intervention versus control arm: The content of this manuscript is solely 36% v 32% in the first year and 31 % v 31 % in the second year.Conclusion Accrual of older patients was not increased by this intervention. Reasons for lack of effect include low intervention intensity, high baseline accrual rates, and closure of several high-accruing protocols during the study. More intense and multifaceted approaches will be of at the end of needed to change physician (and patient) behavior and to increase accrual of older persons to clinical trials. (c) 2005 by American Society of Clinical Oncology.