Preclinical Solid Tumor Models to Study Novel Therapeutics in Brain Metastases.
Preclinical Solid Tumor Models to Study Novel Therapeutics in Brain Metastases.
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DOI：
10.1002/cpz1.284
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Brastianos PK
中科院分区：
文献类型：
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作者：
Singh M;Dahal A;Brastianos PK
转移瘤是成人中枢神经系统最常见的恶性肿瘤，主要由于缺乏成功的治疗选择，正在成为肿瘤学中日益令人不安的问题。治疗选择有限是由于目前对转移发展的生物学机制缺乏了解，而这又难以实现，因为可以准确代表转移临床进展的临床前模型有限。本单元描述了体外和体内模型系统，用于增强对转移的理解，并用于确定治疗脑转移的新疗法。
Metastases are the most common malignancy of the adult central nervous system and are becoming an increasingly troubling problem in oncology largely due to the lack of successful therapeutic options. The limited selection of treatments is a result of the currently poor understanding behind the biological mechanisms of metastatic development, which in turn is difficult to achieve because of limited preclinical models that can accurately represent the clinical progression of metastasis. Described in this unit are in vitro and in vivo model systems that are used to enhance the understanding of metastasis, and for identifying new therapies for the treatment of brain metastasis.