Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease.
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease.
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DOI：
10.3389/fimmu.2021.671052
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发表时间：
2021
影响因子：
7.3
通讯作者：
Thiel S
中科院分区：
文献类型：
--
作者：
Medjeral-Thomas NR;Troldborg A;Hansen AG;Gisby J;Clarke CL;Prendecki M;McAdoo SP;Sandhu E;Lightstone L;Thomas DC;Willicombe M;Botto M;Peters JE;Pickering MC;Thiel S
我们不明白为什么非白人种族和慢性肾脏疾病会增加新冠肺炎的易感性。补体激活的凝集素途径是先天免疫和炎症的关键因素。血浆凝集素途径蛋白浓度影响途径活性，并因种族而异。我们测量了有和没有COVID19感染的多民族慢性肾脏疾病患者的循环凝集素蛋白，以确定凝集素途径的激活是否与COVID19的严重程度有关。我们从33例慢性肾损伤患者和COVID19患者的队列样本中检测了11种凝集素蛋白。对照组为32例透析患者和32例健康人的单一血浆样本。我们证明了识别分子和凝集素途径的相关酶与新冠肺炎之间的多种关联，包括新冠肺炎的严重程度。其中一些关联是亚裔和白人患者独有的。我们的新发现表明，COVID19感染改变了血浆凝集素蛋白的浓度，其中一些变化与种族有关。这表明凝集素途径在宿主对新冠肺炎的反应中发挥了作用，并表明这一途径的变异性可能有助于种族相关的差异对严重新冠肺炎的易感性。
We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation. Concentrations of plasma lectin pathway proteins influence pathway activity and vary with ethnicity. We measured circulating lectin proteins in a multi-ethnic cohort of chronic kidney disease patients with and without COVID19 infection to determine if lectin pathway activation was contributing to COVID19 severity. We measured 11 lectin proteins in serial samples from a cohort of 33 patients with chronic kidney impairment and COVID19. Controls were single plasma samples from 32 patients on dialysis and 32 healthy individuals. We demonstrated multiple associations between recognition molecules and associated proteases of the lectin pathway and COVID-19, including COVID-19 severity. Some of these associations were unique to patients of Asian and White ethnicity. Our novel findings demonstrate that COVID19 infection alters the concentration of plasma lectin proteins and some of these changes were linked to ethnicity. This suggests a role for the lectin pathway in the host response to COVID-19 and suggest that variability within this pathway may contribute to ethnicity-associated differences in susceptibility to severe COVID-19.
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