Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis.
Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis.
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DOI：
10.1016/j.femsle.2005.07.019
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发表时间：
2005-09
影响因子：
2.1
通讯作者：
M. Yamada;A. Ikegami;H. Kuramitsu
中科院分区：
文献类型：
--
作者：
M. Yamada;A. Ikegami;H. Kuramitsu
生物膜的形成是牙周病病因学的一个重要步骤。在本研究中，牙结密螺旋体和牙龈卟啉单胞菌381在体外形成生物膜表现出协同作用。共聚焦显微镜显示p。牙龈菌首先作为主要的定植菌附着在基质上，然后与t共聚集。牙齿形成混合的生物膜。提斯。denticcolaflagella突变体和细胞质丝突变体对生物膜的形成以及与p的共聚集都是必不可少的。gingivalis。主要被毛和arg - gingeppain B。牙龈炎在t的生物膜形成中也起着重要作用。denticola。
Biofilm formation is an important step in the etiology of periodontal diseases. In this study, in vitro biofilm formation byTreponema denticolaandPorphyromonas gingivalis381 displayed synergistic effects. Confocal microscopy demonstrated thatP. gingivalisattaches to the substratum first as a primary colonizer followed by coaggregation withT. denticolato form a mixed biofilm. TheT. denticolaflagella mutant as well as the cytoplasmic filament mutant were shown to be essential for biofilm formation as well as coaggregation withP. gingivalis. The major fimbriae and Arg-gingipain B ofP. gingivalisalso play important roles in biofilm formation withT. denticola.