Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer - preliminary experience.
Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer - preliminary experience.
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DOI：
10.1186/1758-3284-2-31
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发表时间：
2010-10-30
期刊：
影响因子：
--
通讯作者：
Bredell MG
中科院分区：
文献类型：
--
作者：
Bredell MG
前哨淋巴结（SLN）检测和活检在头颈部癌症的治疗中越来越受欢迎。在这方面已经描述了多种方法，每种方法都有各自的优缺点。本文的目的是评估吲哚菁绿（ICG）在头颈部癌症的前哨淋巴结定位和检测中的潜在应用。
选择患有口咽癌且颈部为N0（临床无颈部淋巴结转移）、计划进行原发肿瘤切除以及颈部清扫术的患者。在肿瘤周围注射1毫升吲哚菁绿，通过将红外摄像机对准颈部区域进行前哨淋巴结检测。当经皮无法检测到时，做颈部切口，掀起颈阔肌下皮瓣，进一步检测以观察到发出荧光的淋巴结。
只有当覆盖前哨淋巴结的组织在5毫米或更薄时，才有可能检测到颈部前哨淋巴结。能够准确清晰地检测到淋巴引流模式和前哨淋巴结。在其他组织（如下颌下腺）中也有一些摄取，但很容易与淋巴组织区分开来。
吲哚菁绿荧光是一种在口咽癌患者前哨淋巴结检测中具有潜在价值的工具，值得进一步研究。
Sentinel lymph node (SLN) detection and biopsy is gaining popularity in the treatment of Head and Neck cancer. Various methods in this regard have been described, each with their respective advantages and disadvantages. The aim of this paper was to evaluate the potential application of Indocyanin Green (ICG) in the mapping and detection of sentinel lymph nodes (SLN) in cancers of the head and neck. Patients with oropharyngeal cancer and N0 neck who were scheduled for primary tumor ablation as well as a neck dissection were selected. One milliliter of Indocyanin green was injected around the tumor and the sentinel node detection was performed by aiming the infra red video camera on the cervical area. When no detection was possible transcutaneously, a cervical incision was made, a sub-platysmal flap raised and further detection was done to visualize the fluorescing lymph nodes. Detection of cervical SLN was only possible when 5 mm or less tissue covered the sentinel lymph node. Accurate and clear detection of the lymph drainage pattern and SLN was possible. There is some uptake in other tissues such as the submandibular gland which is easily distinguishable from lymphatic tissue. Indocyanin green fluorescence is a potential valuable potential tool in the detection of SLN in patients with oropharyngeal cancer which warrants further investigation.
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DOI：
10.1007/s00464-006-9062-2
发表时间：
2007-07-01
影响因子：
3.1
作者：
Ishikawa, K.;Yasuda, K.;Kitano, S.
通讯作者：
Kitano, S.
影响因子：
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作者：
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影响因子：
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影响因子：
2.6
作者：
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通讯作者：
Specht, Lena
DOI：
10.1002/hed.20482
发表时间：
2007-01-01
影响因子：
2.9
作者：
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通讯作者：
Naval, Luis