Mutations in the p53 tumor suppressor gene and early onset breast cancer
Mutations in the p53 tumor suppressor gene and early onset breast cancer
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DOI：
10.4161/cbt.1.1.37
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发表时间：
2002-01-01
影响因子：
3.6
通讯作者：
Meng, L
中科院分区：
文献类型：
--
作者：
Lai, H;Lin, L;Meng, L
乳腺癌患者中p53基因突变与预后不良相关年轻女性乳腺癌患者比老年女性预后更差，但p53基因突变是否在年轻女性乳腺癌中起作用尚不清楚。本研究确定了199例乳腺癌患者，并验证了p53基因突变与早发性乳腺癌相关的假设。p53基因突变患者发生早发性乳腺癌（诊断时年龄小于或等于40岁）的可能性是无p53突变患者的3倍（or =3.05, 95% CI= 1.10 -8.45）。同时存在错义突变和沉默突变的患者被诊断为早发性乳腺癌的可能性高出7倍（OR=7.56, 95% CI=2.22-25.8）。p53基因外显子8突变的患者被诊断为早发性乳腺癌的可能性高出6倍（OR=6.48, 95% CI=1.37-30.6）。这些发现提示p53基因突变可能加速女性乳腺癌的发生。
Among breast cancer patients p53 gene mutation is associated with a poor prognosis Young women with breast cancer are more likely than older women to have a poor prognosis, but whether p53 gene mutation plays a role in breast cancer in young women is not clear. This study identified 199 breast cancer patients and tested the hypothesis that p53 gene mutation was associated with early onset breast cancer. Patients with p53 gene mutations were 3-times more likely to have an early onset breast cancer (age less than or equal to 40 years at diagnosis) than those without p53 mutations (OR=3.05, 95% CI=l.l0-8.45). Patients with both missense and silent mutations were 7-times more likely to have a diagnosis of early onset breast cancer (OR=7.56, 95% CI=2.22-25.8). Patients with mutations in exon 8 of the p53 gene were 6-times more likely to be diagnosed with early onset breast cancer (OR=6.48, 95% CI=1.37-30.6). These findings suggest that p53 gene mutation may hasten the onset of female breast cancer.