Nuclear roles for non-lamin intermediate filament proteins.
Nuclear roles for non-lamin intermediate filament proteins.
复制标题
DOI：
10.1016/j.ceb.2023.102303
复制
发表时间：
2023-12
影响因子：
7.5
通讯作者：
Pierre A. Coulombe;Christopher M. Pineda;Justin T. Jacob;R. Nair
中科院分区：
文献类型：
--
作者：
Pierre A. Coulombe;Christopher M. Pineda;Justin T. Jacob;R. Nair
核定位核纤层蛋白一直被认为是唯一的中间丝（IF）的结构，性质和功能的影响的核。然而，最近的研究发现，在各种细胞类型和生物学环境中，除了核纤层蛋白之外的IFs（这里称为“非核纤层蛋白IFs”）在调节细胞核的关键特性中具有重要作用。在细胞质中，IF通常出现在核周空间中，在那里它们有助于局部刚度并影响核的形状和/或完整性，特别是在处于应力下的细胞中。此外，选择性非核纤层蛋白IF蛋白可以在细胞核内发生，在那里它们参与基本过程，包括核结构和染色质组织，基因表达的调节，细胞周期进程和DNA损伤的修复。本文综述了支持非核纤层蛋白IF蛋白在调节细胞核的各种特性中的作用的证据，并强调了进一步研究的机会。
The nuclear-localized lamins have long been thought to be the only intermediate filaments (IFs) with an impact on the architecture, properties, and functions of the nucleus. Recent studies, however, uncovered significant roles for IFs other than lamins (here referred to as “non-lamin IFs”) in regulating key properties of the nucleus in various cell types and biological settings. In the cytoplasm, IFs often occur in the perinuclear space where they contribute to local stiffness and impact the shape and/or the integrity of the nucleus, particularly in cells under stress. In addition, selective non-lamin IF proteins can occur inside the nucleus where they partake in fundamental processes including nuclear architecture and chromatin organization, regulation of gene expression, cell cycle progression, and the repair of DNA damage. This text reviews the evidence supporting a role for non-lamin IF proteins in regulating various properties of the nucleus and highlights opportunities for further study.