Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife - SWAN, the study of women's health across the nation
Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife - SWAN, the study of women's health across the nation
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DOI：
10.1016/j.ajog.2007.11.044
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发表时间：
2008-03-01
影响因子：
9.8
通讯作者：
Santoro, Nanette
中科院分区：
文献类型：
--
作者：
Ram, Kavitha T.;Bobby, Paul;Santoro, Nanette
目的：本研究的目的是评估哺乳期持续时间是否与中年经产女性代谢综合征 (MetSyn) 患病率较低相关。研究设计：这是一项对 2516 名经产中年女性进行的横断面队列分析，使用多变量 Logistic 回归来确定哺乳期和哺乳期持续时间与 MetSyn 患病率的独立关联。结果：1620 名女性 (64.4%) 报告有代谢综合征 (MetSyn) 患病史母乳喂养，平均哺乳期为 1.16 (+/- 1.04) 年。 536 名女性 (21.3%) 中存在 MetSyn。调整年龄、吸烟史、产次、种族、社会经济地位、研究地点、体力活动、热量摄入和高中体重指数后，有哺乳史的女性发生 MetSyn 的几率显着较低（比值比 [OR] 0.79，95% 置信区间 [CI] 0.63 至 0.99）。此外，哺乳持续时间的增加同样与 MetSyn 发生率降低相关（OR 0.88，95% CI 0.77 至 0.99）。结论：在中年经产女性中，哺乳持续时间与 MetSyn 患病率降低存在剂量反应关系。
OBJECTIVE: The objective of the study was to evaluate whether lactation duration is associated with lower prevalence of metabolic syndrome (MetSyn) in midlife, parous women.STUDY DESIGN: This was a cross-sectional cohort analysis of 2516 parous, midlife women using multivariable logistic regression to determine the independent association of lactation and lactation duration on prevalence of MetSyn.RESULTS: One thousand six hundred twenty women (64.4%) reported a history of breast-feeding, with average lifetime duration of lactation of 1.16 (+/- 1.04) years. MetSyn was present in 536 women (21.3%). Adjusting for age, smoking history, parity, ethnicity, socioeconomic status, study site, physical activity, caloric intake, and high school body mass index, women with prior lactation had significantly lower odds of MetSyn ( odds ratio [OR] 0.79, 95% confidence interval [CI] 0.63 to 0.99). Furthermore, increasing duration of lactation was similarly associated with lower odds of MetSyn (OR 0.88, 95% CI 0.77 to 0.99).CONCLUSION: Duration of lactation is associated with lower prevalence of MetSyn in a dose-response manner in midlife, parous women.