Corkscrew-like shortening in single smooth muscle cells.
Corkscrew-like shortening in single smooth muscle cells.
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单个平滑肌细胞出现螺旋状缩短。
DOI：
10.1126/science.3109034
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Work,SS
中科院分区：
文献类型：
--
作者：
Warshaw,DM;McBride,WJ;Work,SS
与骨骼肌相比，平滑肌收缩更慢、更经济，这可能与其收缩装置的排列有关。由于收缩装置的布置决定单个平滑肌细胞缩短的方式，因此通过数字视频显微镜跟踪细胞表面上的标记珠运动来检查收缩细胞的缩短。观察到平滑肌细胞以每秒27度的速度自由缩短，其节距为1.4个细胞长度(即细胞一次完整旋转所需的长度变化)，呈独特的开瓶式缩短。开瓶器状缩短被解释为一种结构模型，在该结构模型中，收缩装置或细胞骨架(或两者)在细胞内螺旋定向。这些细胞结构元素的这种排列可能有助于部分解释平滑肌的收缩能力。
The slower and more economical contraction of smooth muscle as compared to that of skeletal muscle may relate to the arrangement of its contractile apparatus. Because the arrangement of the contractile apparatus determines the manner in which a single smooth muscle cell shortens, shortening of a contracting cell was examined by tracking of marker bead movements on the cell surface by means of digital video microscopy. Smooth muscle cells were observed to freely shorten in a unique corkscrew-like fashion with a pitch of 1.4 cell lengths (that is, the length change required for one complete rotation of cell) at a rate of 27 degrees per second. Corkscrew-like shortening was interpreted in terms of a structural model in which the contractile apparatus or cytoskeleton (or both) are helically oriented within the cell. Such an arrangement of these cytoarchitectural elements may help to explain in part the contractile capabilities of smooth muscle.