Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts
Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts
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DOI：
10.1021/ja036972z
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发表时间：
2003-10-22
影响因子：
15
通讯作者：
Takemoto, Y
中科院分区：
文献类型：
--
作者：
Okino, T;Hoashi, Y;Takemoto, Y
丙二酸酯与含硫脲和叔氨基的手性双功能有机催化剂的Michael反应生成硝基烯烃，使Michael加合物具有高收率和对映选择性（高达95%，高达93% ee）。
Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).