Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: ultrastructural features and differential diagnosis.
Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: ultrastructural features and differential diagnosis.
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DOI：
10.3109/01913123.2014.950778
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发表时间：
2015-02
影响因子：
1
通讯作者：
Bhattacharjee MB
中科院分区：
文献类型：
--
作者：
Cykowski MD;Hicks J;Sandberg DI;Olar A;Bridge JA;Greipp PT;Navarro P;Kolodziej S;Bhattacharjee MB
我们报告一例以孤立性额叶转移为表现的肺泡状软组织肉瘤。肿瘤对一系列抗体的免疫反应性很低，甚至没有，但对CD68有很强的弥漫性免疫反应。在电子显微镜下，未见典型的矩形至菱形晶体包裹体。类似于过氧化体的电子致密颗粒存在，有时与具有周期性格子样排列的细长颗粒结构相关联。ASPSCR1-TFE3融合和排除转移性Xp11.2转移性肾细胞癌的影像研究证实为转移性ASPS。主要部位随后被确定在下肢。
We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, characteristic rectangular to rhomboid crystalline inclusions were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.